Browse > Article
http://dx.doi.org/10.7317/pk.2012.36.4.455

Preparation of PNIPAM Hydrogel Containing Lipoic Acid  

Yoon, Hye-Ri (Department of Chemical Engineering and Materials Science, Chung-Ang University)
Lee, Jong-Hwi (Department of Chemical Engineering and Materials Science, Chung-Ang University)
Publication Information
Polymer(Korea) / v.36, no.4, 2012 , pp. 455-460 More about this Journal
Abstract
Poly(N-isopropylacrylamide) (PNIPAM) hydrogel has been studied as an important drug delivery system due to its volume transition or temperature-responsive swelling properties, whose phase separation temperature is similar to the body temperature. However, because of hydrophilic PNIPAM, hydrophobic drugs are difficult to be uniformly loaded in the networks. Antioxidant alpha-lipoic acid (LA) can be prepared as a polymer(polylipoic acid, PLA) by ring opening polymerization, which is hardly developed as a material due to its low molecular weight and easy depolymerization. To overcome this limitation, a hydrophobic active ingredient, LA was reacted with NIPAM into stable hydrogels. Simple thermal radical reaction successfully resulted in a hydrogel (PNIPAM/PLA), which was confirmed by DSC, FTIR, and Raman spectroscopy. The PNIPAM/PLA showed temperature-responsive properties, and their volume swelling decreased with an increase in lipoic acid content. These hydrogels can carry hydrophobic drugs with PNIPAM and the hydrogels could be useful as final drug delivery systems having lipoic acid as an antioxidant.
Keywords
alpha-lipoic acid; poly(N-isopropylacrylamide); hydrogel; temperature-responsive; drug delivery;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 B. C. Shin, M. S. Jhon, H. B. Lee, and S. H. Yuk, Eur. Polym. J., 34, 1675 (1998).   DOI   ScienceOn
2 J. Gu, F. Xia, Y. Wu, X. Qu, Z. Yang, and L. Jiang, J. Control. Release, 117, 396 (2007).   DOI   ScienceOn
3 H. Kasgoz, A. Durmus, and A. Kasgoz, Polym. Adv. Technol., 19, 213 (2008).   DOI   ScienceOn
4 Y. S. Park, H. D. Han, S. U. Hong, S. S. Kim, and B. C. Shin, Polymer(Korea), 28, 59 (2004).
5 M. K. Kang and J. C. Kim, Polymer(Korea), 34, 79 (2010).
6 H. C. Noh, C. W. Lee, S. Y. Park, and K. S. Yoon, Polymer(Korea), 34, 166 (2010).
7 G. P. Biewenga, G. R. M. M. Haenen, and A. Bast, Lipoic Acid in Health and Disease, Marcel Dekker, New York, 1997.
8 S. Roy and L. Parker, Biofactors, 8, 17 (1998).   DOI
9 R. H. Bisby, S. A. Johnson, and A. W. Parker, Biol. Med., 20, 411 (1996).
10 C. H. Park, A. R. Kim, H. L. Yun, and J. Lee, Polymer(Korea), 30, 357 (2006).
11 J. Ma, Y. Xu, B. Fan, and B. Liang, Eur. Polym. J., 43, 2221 (2007).   DOI   ScienceOn
12 Y.-H. Kim, I. C. Kwon, and S. Y. Jeong, Polymer Science and Technology, 5, 544 (1994).
13 C. Sayil and O. Okay, Polym. Bull., 48, 499 (2002).   DOI   ScienceOn
14 H. Feil, Y. H. Bae, J. Feijen, and S. W. Kim, Macromolecules, 26, 2496 (1993).   DOI   ScienceOn
15 Y. H. Bae, T. Okano, and S. W. Kim, Pharm. Res., 8, 531 (1991).   DOI
16 X. Xia, Z. Hu, and M. Marquez, J. Control. Release, 103, 21 (2005).   DOI   ScienceOn