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http://dx.doi.org/10.7317/pk.2012.36.3.332

Effect of Particle Size of HPMC on Dissolution Rate of Venlafaxine HCl and Carbamazepine Sustained Release Tablet  

Cha, Jae-Uk (Samsung Fine Chemicals Co., Ltd.)
Cha, Ja-Hyun (Samsung Fine Chemicals Co., Ltd.)
Hong, Jun-Kee (Samsung Fine Chemicals Co., Ltd.)
Lee, Sung-Wan (Samsung Fine Chemicals Co., Ltd.)
Ko, Won-Hwa (Samsung Fine Chemicals Co., Ltd.)
Beak, Hyun-Ho (Samsung Fine Chemicals Co., Ltd.)
Publication Information
Polymer(Korea) / v.36, no.3, 2012 , pp. 332-337 More about this Journal
Abstract
The primary objective of this work is to find the properties of sustained release dissolution pattern depending on solubility of drugs, so venlafaxine HCl and carbamazepine tablets were made by using polymer wich various particle size. Hydroxy propyl methyl cellulose (HPMC) has been utilized in this study as an excipient that is one of the most widely used polymers for an oral sustained release formulation, and drug release pattern was strongly influenced by swelling rate depending on particle size of HPMC. Scanning electron microscope (SEM) was employed to investigate the surface of tablets with various HPMC particle size, and differential scanning calorimeter (DSC) was employed to investigate the crystallization of drugs in tablets. The release model equation was applied to analyze the main mechanism of drug release pattern. The results demonstrate that drug release pattern is controlled by the drug solubility and HPMC particle size.
Keywords
HPMC; sustained release; venlafaxine HCl; carbamazepine; AnyCoat-C;
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