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http://dx.doi.org/10.7317/pk.2012.36.3.295

Synthesis of Dendrimer with PEG Core by Click Chemistry  

Han, Seung-Choul (Department of Medical Bioscience, Dong-A University)
Jin, Sung-Ho (Department of Chemistry Education, Pusan National University)
Lee, Jae-Wook (Department of Medical Bioscience, Dong-A University)
Publication Information
Polymer(Korea) / v.36, no.3, 2012 , pp. 295-301 More about this Journal
Abstract
Efficient stitching methods for the synthesis of Fr$\acute{e}$chet-type dendrimers with linear PEG units at a core were elaborated. The synthetic strategy involved an inexpensive 1,3-dipolar cycloaddition reaction between an alkyne and an azide in the presence of Cu(I) species which is known as the best example of click chemistry. The linear core building blocks, two diazido-PEG units, were chosen to serve as the azide functionalities for dendrimer growth via click reactions with the alkyne-dendrons. These two building blocks were employed together with the alkyne-functionalized Fr$\acute{e}$chet-type dendrons in a convergent strategy to synthesize two kinds of Fr$\acute{e}$chet-type dendrimers with different linear core units.
Keywords
alkyne; azide; click chemistry; dendrimers;
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Times Cited By KSCI : 2  (Citation Analysis)
Times Cited By Web Of Science : 3  (Related Records In Web of Science)
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