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Preparation of Eudragit Coated Superporous Hydrogels and Their pH Dependent Swelling Behavior  

Kim, Bo-A (Department of Polymer Science and Engineering, Chungnam National University)
Baek, Eun-Jung (Department of Polymer Science and Engineering, Chungnam National University)
Huh, Kang-Moo (Department of Polymer Science and Engineering, Chungnam National University)
Publication Information
Polymer(Korea) / v.35, no.6, 2011 , pp. 520-525 More about this Journal
Abstract
Superporous hydrogels (SPHs) with fast swelling and superabsorbent properties are useful materials in various biomedical fields, by improving the swelling properties of conventional hydrogels based on their unique porous structure. In this study, Eudragit polymers were used as coating materials to control the swelling properties of poly(acrylic acid-co-acrylamide) based SPHs by environmental pH. The SPHs were coated with Eudragit L100 and S100 that have different pH characteristics as enteric coating materials by a dip coating method, and their pH dependent swelling behaviors were observed in various pH environments. The swelling of SPHs was inhibited at a low pH range, but significantly enhanced above a characteristic pH of Eudragit polymers. This pH dependent swelling behavior of hydrogels could be modulated by the characteristics of the enteric coating polymers.
Keywords
superporous hydrogels; fast swelling; Eudragit coating; pH dependent swelling;
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