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Coaxial Nozzle Electrospraying of Polymer Solutions: Use of Dispersant Flow  

Kim, Min-Young (Department of Chemical Engineering and Materials Science, Chung-Ang University)
Lee, Jong-Hwi (Department of Chemical Engineering and Materials Science, Chung-Ang University)
Publication Information
Polymer(Korea) / v.35, no.3, 2011 , pp. 254-259 More about this Journal
Abstract
In electrospraying of polymer solutions, metal sample collectors are often ineffective in fully removing solvent from sprayed particles and recovering redispersable sprayed particles. Herein, a novel electro spraying system, where sprayed particles were dispersed into laminar flow of dispersant (coagulation liquid), was designed for the nano-encapsulation of protein drugs. Chitosan and polyacrylic acid were used as the encapsulation materials. Aggregation of particles could be prevented by using this new electrospraying system, and unimodal size distribution was observed at an applied voltage between 4~16 kV and a low flow rate. The effects of the applied voltage on mean particle size were not significant on the other hand.
Keywords
electrospraying; chitosan; nanoparticles; drug delivery; protein;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
Times Cited By Web Of Science : 0  (Related Records In Web of Science)
Times Cited By SCOPUS : 0
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