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Fabrication and Biocompatibility of Rutin-containing PHBV Nanofibrous Scaffolds  

Chae, Won-Pyo (Department of Polymer Science & Engineering, Kyungpook National University)
Xing, Zhi-Cai (Department of Polymer Science & Engineering, Kyungpook National University)
Kim, Yong-Jin (Department of Biomedical Engineering, Catholic University of Deagu)
Sang, Hie-Sun (School of Fire-Protecting Technology. Kyungil University)
Huh, Man-Woo (School of Textile and Fashion Technology, Kyungil University)
Kang, Inn-Kyu (Department of Polymer Science & Engineering, Kyungpook National University)
Publication Information
Polymer(Korea) / v.35, no.3, 2011 , pp. 210-215 More about this Journal
Abstract
Rutin (R) exhibits a wide range of biological activities including anticarcinogenic, antiinflammatory and antiviral actions. The purpose of this study is to investigate the effect of rutin concentrations (1 and 3 wt%) on the antibacterial activity of poly(3-hydroxybutylate-co-hydroxyvalerate) (PHBV) scaffolds. Antibacterial activity was evaluated by using Staphylococcus aureus and Klebsiella pneumoniae. Furthermore, the qualitative ongrowth of human KB endothelial cells was done to study in vitro cytotoxicity of the scaffolds. As the results, PHBV scaffolds containing 3 wt% rutin completely inhibited the proliferation of Staphylococcus aureus and Klebsiella pneumoniae. In addition, the PHBV/R scaffolds used in this study did not show any cytotoxicity when evaluated them with KB endothelial cells.
Keywords
cytotoxicity; antibacterial; rutin; PHBV; KB cell;
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