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Ultrasmall Polyethyleneimine-Gold Nanoparticles with High Stability  

Kim, Eun-Jung (Department of Advanced Organic Materials Science and Engineering, Kyungpook National University)
Yeum, Jeong-Hyun (Department of Advanced Organic Materials Science and Engineering, Kyungpook National University)
Ghim, Han-Do (Department of Advanced Organic Materials Science and Engineering, Kyungpook National University)
Lee, Se-Guen (Division of Nano & Bio Technology, Daegu Gyungbuk Institute of Science & Technology)
Lee, Ga-Hyun (Division of Functional Crop Resource Development, Department of Functional Crop, National Institute of Crop Science)
Lee, Hyun-Ju (Department of Advanced Organic Materials Science and Engineering, Kyungpook National University)
Han, Sang-Ik (Division of Functional Crop Resource Development, Department of Functional Crop, National Institute of Crop Science)
Choi, Jin-Hyun (Department of Advanced Organic Materials Science and Engineering, Kyungpook National University)
Publication Information
Polymer(Korea) / v.35, no.2, 2011 , pp. 161-165 More about this Journal
Abstract
This study is related to the preparation of biocompatible gold nanoparticles (AuNPs) which are stable in aqueous solutions for a long time. Ultrasmall polyethyleneimine (PEI)-capped AuNPs (PEI-AuNPs) with limited agglomeration were prepared in aqueous solutions at room temperature, which were based on the roles of PEI as a reductant and a stabilizer. PEI-AuNPs with an average size of 8~12 nm formed highly stable nanocolloids with an average hydrodynamic cluster size of around 50 nm in aqueous media. At a low concentration of metal precursor hydrogen tetrachloroaurate (III), the particle size was reduced noticeably. The typical peaks of gold were observed in the X-ray diffraction pattern of AuNPs. The cell viability of 98% was obtained in the case of PEI-AuNPs, while PEI was cytotoxic. The PEI-AuNP is considered to be a potential candidate as a contrast agent for computed tomography.
Keywords
gold; nanoparticles; polyethyleneimine; reductant; stabilizer;
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