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Preparation and Characterization of Deoxycholic Acid-Grafted Hyaluronic Acid as a Durg Carrier  

Choi, Chang-Yong (Department of Polymer Science and Engineering, Sunchon National University)
Park, Jun-Kyu (Department of Polymer Science and Engineering, Sunchon National University)
Kim, Won-Suk (Department of Polymer Science and Engineering, Sunchon National University)
Jang, Mi-Kyeong (Department of Polymer Science and Engineering, Sunchon National University)
Nah, Jae-Woon (Department of Polymer Science and Engineering, Sunchon National University)
Publication Information
Polymer(Korea) / v.35, no.2, 2011 , pp. 119-123 More about this Journal
Abstract
To develop hyaluronic acid (HA)-based anticancer agent carrier, hyaluronic acid was chemically modified with the hydrophobic group of deoxycholic acid(DA). The physicochemical properties of the deoxycholic acid-conjugated HA (HADA) were investigated by using $^1H$ NMR, FTIR spectrophotometer and TEM. Paclitaxel (Tx)-loaded HADA nanoparticles were prepared by a dialysis method. The loading efficiency of drug and drug contents of Tx-loaded HADA nanoparticles (HADA-Tx) were measured by HPLC. The anticancer activity of HADA-Tx was investigated by its cytotoxicity against KB cell in vitro. The HADA-Tx was shown to have the superior potential for the anticancer drug delivery.
Keywords
hyaluronic acid; bile acid; deoxycholic acid; drug carrier; nanoparticle;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 1  (Related Records In Web of Science)
Times Cited By SCOPUS : 1
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