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Preparation and Characterization of Pioglitazone Loaded PLGA Nanospheres for the Treatment of Type 2 Diabetes  

Woo, Hyun-Ju (Department of Chemical and Biological Engineering, Chungju National University)
Kim, Jin-Soo (Department of Chemical and Biological Engineering, Chungju National University)
Kim, Jun-Gi (Department of Chemical and Biological Engineering, Chungju National University)
Nurunnabi, Md. (Department of Chemical and Biological Engineering, Chungju National University)
Huh, Kang-Moo (Department of Polymer Science and Engineering, Chungnam National University)
Cho, Kwang-Jae (Department of Otolaryngology-Head & Neck Surgery, The Catholic University of Korea, College of Medicine Uijeongbu St. Mary's Hospital)
Lee, Yong-Kyu (Department of Chemical and Biological Engineering, Chungju National University)
Publication Information
Polymer(Korea) / v.34, no.6, 2010 , pp. 527-533 More about this Journal
Abstract
The pioglitazone loaded poly(lactide-co-glycolide)(PLGA) nanospheres were prepared by emulsion-evaporation method and optimized for particle size and entrapment efficiency. The optimized particles were 125~170 nm in size with narrow size distribution and showed above 85% entrapment efficiency at 30% of pioglitazone loading when prepared with 3% w/v of poly(vinyl alcohol) (PVA) as a surfactant. These particulate carriers exhibited a controlled in vitro release of pioglitazone for 40 days at a nearly constant rate. The pioglitazone loaded PLGA nanospheres were not only effective to reduce the blood sugar level of diabetic rats but also non-toxic for the animal body, in particular for sensitive organs like kidney, liver, heart, lung and spleen. These results indicate that PLGA nanospheres have a great potential for oral delivery of pioglitazone.
Keywords
pioglitazone; PLGA nanospheres; type 2 diabetes; drug delivery; controlled release;
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