Browse > Article

Preparation and Characterization of L-Arginine Containing Poloxamer Hydrogels for Solubilization and Sustained Release of Amphotericin B  

Shin, Baek-Ki (College of Pharmacy, Chungnam National University)
Baek, Eun-Jung (Department of Polymer Science and Engineering, Chungnam National University)
Kim, Ye-Tae (College of Pharmacy, Chungnam National University)
Jeong, Ji-Woong (College of Pharmacy, Chungnam National University)
Nho, Young-Chang (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute)
Lim, Youn-Mook (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute)
Park, Jong-Seok (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute)
Huh, Kang-Moo (Department of Polymer Science and Engineering, Chungnam National University)
Park, Jeong-Sook (College of Pharmacy, Chungnam National University)
Publication Information
Polymer(Korea) / v.34, no.5, 2010 , pp. 459-463 More about this Journal
Abstract
Amphotericin B (AmB) is anti-fungal agent for the treatment of systemic fungal infections, but its poor solubility has limited clinical applications. In this study, a new gel formulation made up of L-arginine as solubilizer, thermosensitive Poloxamer 407 (P 407), and adhesive carbopol was designed for effective solubilization and delivery of AmB. The aqueous solubility of AmB was enhanced up to 2.6 mg/mL by addition of L-arginine. Aqueous P 407 solutions of more than 20% w/v showed thermo-induced sol-gel-sol phase transition. The phase transition behavior was affected by the presence of AmB and L-arginine, and the phase transition range was broadened by addition of carbopol. In vitro drug release was improved by the solubilizing effect of L-arginine, and the presence of mucoadhesive carbopol prolonged the release rate as a function of concentration.
Keywords
Poloxamer; amphotericin B; L-arginine; solubility; sustained release;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 1  (Related Records In Web of Science)
Times Cited By SCOPUS : 1
연도 인용수 순위
1 T. Arakawa, K. Tsumoto, K. Nagase, and D. Ejima, Protein Expres. Purif., 54, 110 (2007).   DOI   ScienceOn
2 P. Alexandridis and T. A. Hatton, Colloid Surface A, 96, 1 (1995).   DOI   ScienceOn
3 M. Malmsten, Soft Matter, 2, 760 (2006).   DOI   ScienceOn
4 K. Morikawa, F. Okada, M. Hosokawa, and H. Kobayashi, Cancer Res., 47, 37 (1987).
5 R. Bhardwaj and J. Blanchard, J. Pharm. Sci., 85, 915 (1996).   DOI   ScienceOn
6 S. D. Desai and J. Blanchard, J. Pharm. Sci., 87, 226 (1998).   DOI   ScienceOn
7 S. C. Shin, J. Y. Kim, and I. J. Oh, Drug Dev. Ind. Pharm., 26, 307 (2000).   DOI   ScienceOn
8 M. Kleinberg, Int. J. Antimicrob. Ag., 27S, S12 (2006).
9 E. J. Ricci, M. V. L. B. Bentley, M. Farah, R. E. S. Bretas, and J. M. Marchetti, Eur. J. Pharm. Sci., 17, 161 (2002).   DOI   ScienceOn
10 R. G. Laughlin, Aqueous Phase Behavior of Surfactants, Academic Press, London, 1994.
11 J. Mazerski and E. Borowski, Biophys. Chem., 57, 205 (1996).   DOI   ScienceOn
12 J. Bolard, Biochim. Biophys. Acta, 864, 257 (1986).   DOI   ScienceOn
13 T. Arakawa and K. Tsumoto, Biochem. Biophys. Res. Commun., 304, 148 (2003).   DOI   ScienceOn
14 J. Brajtburg, S. Elberg, D. R. Schwartz, A. Vertut-Croquin, D. Schlessinger, G. S. Kobayashi, and G. Medoff, Antimicrob. Agents Chemother., 27, 172 (1985).   DOI   ScienceOn
15 M. Nahar, D. Mishra, V. Dubey, and N. K. Jain, Nanomedicine, 4, 252 (2008).   DOI   ScienceOn
16 A. Lavasanifar, J. Samuel, and G. S. Kwon, J. Control. Release, 79, 165 (2002).   DOI   ScienceOn
17 T. Arakawa, Y. Kita, D. Ejima, K. Tsumoto, and H. Fukada, Protein Peptide Lett., 13, 921 (2006).   DOI   ScienceOn
18 T. Arakawa, Y. Kita, D. Ejima, K. Tsumoto, and H. Fukada, Protein Peptide Lett., 13, 921 (2006).   DOI   ScienceOn
19 T. Arakawa, K. Tsumoto, Y. Kita, B. Chang, and D. Ejima, Amino Acids, 33, 587 (2007).   DOI   ScienceOn
20 D. Ejima, R. Yumioka, T. Arakawa, and K. Tsumoto, J. Chromatogr. A, 1094, 49 (2005).   DOI   ScienceOn
21 K. Tsumoto, D. Ejima, K. Nagase, and T. Arakawa, J. Chromatogr. A, 1154, 81 (2007).   DOI   ScienceOn
22 P. Wang and T. P. Johnston, Int. J. Pharm., 113, 73 (1995).   DOI   ScienceOn
23 Y. G. Han, J. W. Kwon, H. Y. Kim, J. S. Kim, J. S. Jo, W. L. Wi, and J. H. Lee, J. Korean Ophthal. Soc., 44, 2137 (2003).