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Effect of Newly Developed Pectin/CMC Dressing Materials on Three Different Types of Wound Model  

Lim, Hyun-Ju (Kyungpook National University, Department of Advanced Organic Materials Science and Engineering)
Kim, Hak-Tae (Kyungpook National University, School of Medicine, Department of Plastic & Reconstructive Surgery)
Oh, Eun-Jung (Kyungpook National University, Department of Advanced Organic Materials Science and Engineering)
Choi, Jin-Hyun (Kyungpook National University, Department of Advanced Organic Materials Science and Engineering)
Ghim, Han-Do (Kyungpook National University, Department of Advanced Organic Materials Science and Engineering)
Pyun, Do-Gi (Sungkyunkwan University, Department of Polymer Science and Engineering)
Lee, Soo-Bok (R&D Center of Texanmedtech. Co., Ltd.)
Chung, Dong-Jun (Sungkyunkwan University, Department of Polymer Science and Engineering)
Chung, Ho-Yun (Kyungpook National University, School of Medicine, Department of Plastic & Reconstructive Surgery)
Publication Information
Polymer(Korea) / v.34, no.4, 2010 , pp. 363-368 More about this Journal
Abstract
Adequate acidic environment in wound healing prevents the inflammation of virus, increases the cell activity, promotes cell proliferation and regular rearrangement of fibroblast, and results in matured epithelialization. In this study, we prepared dressing materials consisting of pectin and carboxymethylcellulose (CMC) with varied ratios. These dressing materials showed different pH values according to the composition ratio. The effect of acidity of pectin/CMC dressing materials on wound healing rates, degree of epithelialization, collagen deposition, and so on, in 3 types of wound models (fresh surgical wounds, $3^{rd}$ degree burn wounds, and infection wounds) were investigated by animal tests. From the results of wound contraction, wound healing, and epithelialization, it can be deduced that dressing material having pectin/CMC ratio of 16/19 (pH 4.67) is most effective among the 3 types of wound models.
Keywords
pectin/CMC; wound healing; dressing materials;
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