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Controlled Release of Paclitaxel from Biodegradable Polymer Films for Drug-Eluting Stents  

Kim, Si-Eun (Biomaterials Center, Korea Institute of Science and Technology)
Lee, Bong-Soo (Biomaterials Center, Korea Institute of Science and Technology)
Kim, Jin-Hyang (Biomaterials Center, Korea Institute of Science and Technology)
Park, Kwi-Deok (Biomaterials Center, Korea Institute of Science and Technology)
Han, Dong-Keun (Biomaterials Center, Korea Institute of Science and Technology)
Publication Information
Polymer(Korea) / v.34, no.2, 2010 , pp. 172-177 More about this Journal
Abstract
Although many researchers have studied the efficacy of paclitaxel (PTX) on many cells during the last two decades, little work has been reported on the importance of release kinetics inhibiting cell proliferation. The aim of this study is to examine the release behavior of the PTX on various biodegradable polymers such as poly(lactic-co-glycolic acid)(PLGA), poly-L-lactide (PLLA), and polycaprolactone (PCL) for drug-eluting stents (DES). The PTX from the fabricated films was released for 8 weeks and the degree of degradation of the films was observed by FE-SEM. Although the degradation time of PCL was the slowest, the PTX release rate was the fastest among them and followed by PLGA and PLLA with the equivalent PTX concentration. It suggests that hydrophobic drug such as PTX from polymer with low $T_g$ like PCL could be moved easily and released rapidly in body temperature.
Keywords
drug-eluting stents(DES); biodegradable polymer; paclitaxel(PTX); controlled release; degradation;
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