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Preparation and Release Property of Alginate Beads Immobilizing Poly(N-isopropylacrylamide-co-dimethylamino ethyl methacrylate)  

Kang, Mi-Kyoung (School of Biotechnology & Bioengineering and Institute of Bioscience and Biotechnology, Kangwon National University)
Kim, Jin-Chul (School of Biotechnology & Bioengineering and Institute of Bioscience and Biotechnology, Kangwon National University)
Publication Information
Polymer(Korea) / v.34, no.1, 2010 , pp. 79-83 More about this Journal
Abstract
Alginate beads were prepared using poly(N-isopropylacrylamide-co-dimethylamino ethyl methacrylate)(P(NIPAM-co-DMAEMA)). First, P(NIPAM-co-DMAEMA) was immobilized on the surface of alginate beads by taking advantage of electrostatic interaction between alginate and P(NIPAM-co-DMAEMA). Second, P(NIPAM-co-DMAEMA) was contained in the matrix of alginate beads. P(NIPAM-co-DMAEMA) were prepared by a free radical polymerization at $74^{\circ}C$ for 12 h. The weight ratio of NIPAM to DMAEMA monomer was 95/5. The copolymer was identified by $^1H$-NMR. Releases from the alginate beads were observed at 30, 37, and $45^{\circ}C$ using blue dextran or FITC-dextran(fluorescein isothiocyanate-dextran) as a model drug. The effect of temperature on the degree of release from the beads was insignificant. FITC-dextran was released more than blue dextran possibly due to its smaller molecular weight.
Keywords
alginate beads; N-isopropylacrylamide; dimethylamino ethyl methacrylate; release property;
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