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Preparation and Characterization of Biodegradable Superporous Hydrogels  

Yuk, Kun-Young (Department of Polymer Science and Engineering, Chungnam National University)
Choi, You-Mee (Department of Polymer Science and Engineering, Chungnam National University)
Park, Jeong-Sook (College of Pharmacy, Chungnam National University)
Kim, So-Yeon (Division of Engineering Education, College of Engineering, Chungnam National University)
Park, Ki-Nam (Purdue University, Departments of Pharmaceutics and Biomedical Engineering, School of Pharmacy)
Huh, Kang-Moo (Department of Polymer Science and Engineering, Chungnam National University)
Publication Information
Polymer(Korea) / v.33, no.5, 2009 , pp. 469-476 More about this Journal
Abstract
In this study, biodegradable superporous hydrogels(SPHs) with fast swelling and superabsorbent properties were prepared using biodegradable crosslinkers and their physicochemical properties were characterized. A biodegradable crosslinker (PLA-PEG-PLA DA) was synthesized by a ring opening polymerization of D,L-lactide (LA) using hydrophilic poly(ethylene glycol) as a macroinitiator, followed by diacrylation of the end groups for the introduction of polymerizable vinyl groups. Various kinds of hydrogels with different chemical compositions were prepared and characterized in terms of swelling ratio, swelling kinetics, and biodegradation properties. The synthetic results were confirmed by $^1H$-NMR, FT-IR and GPC measurements, and the porous structures of the prepared SPHs and their porosities were identified by a scanning electron microscope and mercury porosimetry, respectively. The physicochemical properties of SPHs could be controlled by varying their chemical compositions and their cytotoxicity were found to be very low by MTT assay.
Keywords
biodegradable hydrogel; fast swelling; superabsorbent; superporous hydeogel; PLA-PEG-PLA;
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