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Norfloxacin-Incorporated Polymeric Micelle Composed of Poly(ε-caprolactone)/Poly(ethylene glycol) Diblock Copolymer  

Jeong, Young-Il (Department of Polymer Science and Engineering, Sunchon National University)
Jang, Mi-Kyeong (Department of Polymer Science and Engineering, Sunchon National University)
Nah, Jae-Woon (Department of Polymer Science and Engineering, Sunchon National University)
Publication Information
Polymer(Korea) / v.33, no.2, 2009 , pp. 137-143 More about this Journal
Abstract
We prepared norfloxacin (NFX)-incorporated polymeric micelle using poly ($\varepsilon$-caprolactone)/poly(ethylene glycol) (PCL/PEG, CE) diblock copolymers. Particle size was from 60 to 200 nm according to the PCL block length. Their critical association concentration (CAC) was decreased according to the increase of PCL block length. $^1H$-NMR study showed core-shell type micelle structures of CE diblock copolymers in the aqueous environment. Drug release from polymeric micelle was continued over 2 days. Duration of drug release was varied according to the PCL block length and drug contents. At antimicrobial activity test, polymeric micelle showed almost similar cytotoxicity compared to NFX itself.
Keywords
polymeric micelle; norfloxacin; biodegradable polymer; antimicrobial agent; diblock copolymer;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
Times Cited By Web Of Science : 1  (Related Records In Web of Science)
Times Cited By SCOPUS : 1
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