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Self-Aggregated Nanoparticles of Lipoic Acid Conjugated Hyaluronic Acid  

Hong, In-Rim (Department of Nano Technology, Chungnam National University)
Kim, Young-Jin (Department of Applied Chemistry & Biological Engineering, Chungnam National University)
Publication Information
Polymer(Korea) / v.32, no.6, 2008 , pp. 561-565 More about this Journal
Abstract
Hyaluronic acid (HA) is a natural glycosaminoglycan and is used widely in the pharmaceutical field. Lipoic acid (LA) helps the regeneration of exogenous and endogenous antioxidants such as Vitamin C and Vitamin E as well as glutathione. It also acts as antioxidant indirectly. Hydrophilic HA as a biodegradable and biocompatible polymer was conjugated with hydrophobic LA as an antioxidant to form the graft copolymer. The carboxyl group of HA was modified by adipic acid dihydrazide (ADH). The synthesis of HA-g-LA graft copolymers was characterized by FT-IR, $^1H$-NMR spectroscopy. The conjugates could form the self-assembled nanoparticles in aqueous solution. The particle size and critical aggregation concentration were verified to use the nanoparticle as a carrier fur the hydrophobic material.
Keywords
hyaluronic acid; lipoic acid; graft copolymer; antioxidant;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 2  (Related Records In Web of Science)
Times Cited By SCOPUS : 0
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