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Characterization of Lactide/Hyaluronic Acid Polymer Cross-Linked by 1,3-Butadiene Diepoxide  

Han, Gwang-Seon (Department of Chemical Engineering and Nano-Bio Technology, Hannam University)
Bae, Jung-Eun (Department of Biological Sciences, Hannam University)
Kim, In-Seop (Department of Biological Sciences, Hannam University)
Cheong, Seong-Ihl (Department of Chemical Engineering and Nano-Bio Technology, Hannam University)
Publication Information
Polymer(Korea) / v.32, no.4, 2008 , pp. 390-396 More about this Journal
Abstract
The hyaluronic acid (HA) polymers cross-linked with lactide (LA) using the crosslinking agent, 1,3-butadiene diepoxide (BD), were prepared in order to develop a biomedical material for tissue engineering. The degree of lactide and BD reaction of the crosslinked polymer was determined by the analysis of nuclear magnetic resonance spectroscopy. Both degree of reaction and swelling ratio increased with BD concentration or LA/HA mole ratio. Tensile modulus decreased with increasing BD concentration or decreasing LA/HA mole ratio. Degradation was shown to be progressed at two different stages and became slow with increasing BD concentration. It was shown that the first stage degradation was mainly due to the decomposition of ester linkage in the crosslinked structure. The cell growth inhibition increased with BD concentration. Although cytotoxicity was slightly observed in the high BD concentration, the value was very low (below 6%) enough not to affect the cell growth.
Keywords
biodegradable polymer; hyaluronic acid; lactide; l,3-butadiene diepoxide; cytotoxicity;
Citations & Related Records
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Times Cited By Web Of Science : 0  (Related Records In Web of Science)
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