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Preparation and Characterization of Lithocholic Acid Conjugated Chitosan Oligosaccharide Nanoparticles for Hydrophobic Anticancer Agent Carriers  

Park, Jun-Kyu (Bioalpha Co.)
Kim, Dong-Gon (Department of Polymer Science and Engineering, Sunchon National University)
Choi, Chang-Yong (Department of Polymer Science and Engineering, Sunchon National University)
Jeong, Young-Il (Department of Polymer Science and Engineering, Sunchon National University)
Kim, Myung-Yul (Department of Polymer Science and Engineering, Sunchon National University)
Jang, Mi-Kyeong (Department of Polymer Science and Engineering, Sunchon National University)
Nah, Jae-Woon (Department of Polymer Science and Engineering, Sunchon National University)
Publication Information
Polymer(Korea) / v.32, no.3, 2008 , pp. 263-269 More about this Journal
Abstract
To develop carriers of hydrophobic anticancer agents based on chitosan, chitosan oligosaccharide lactate (COS) was chemically modified with lithocholic acid (LA) which is one of the bile acids as a hydrophobic group. The physicochemical properties of the lithocholic acid conjugated chitosan nanoparticles (COS-LA) were investigated using $^1H$-NMR spectroscopy, dynamic light scattering (DLS) and spectrofluorophotometer. COS-LA-paclitaxel (CLs-Tx) nanoparticles loading paclitaxel as an anticancer agent were prepared by a dialysis method and its loading efficiency was measured through HPLC. On the basis of DLS results, the estimated particle sizes of CLs-Tx were around 300 nm. Also, the critical micelle concentration (CMC) was proven to be dependent on the degree of substitution of lithocholic acid. It showed that the CLs-Tx has the superior potential for the application as a paclitaxel carrier.
Keywords
chitosan; nanoparticle; anticancer agent; lithocholic acid; paclitaxel;
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