Browse > Article

Evaluation of the Stability of Biodegradable Nanoparticle with Time via Particle Size Measurement  

Cho, Kuk-Young (Division of Advanced Materials Engineering, Kongju National University)
Yim, Jin-Heong (Division of Advanced Materials Engineering, Kongju National University)
Park, Jung-Ki (Department of Chemical & Biomolecular Engineering, Korea Advanced Institute of Science and Technology)
Lee, Ki-Seok (Department of Mechanical Engineering & Automotive Engineering, Kongju National University)
Publication Information
Polymer(Korea) / v.32, no.3, 2008 , pp. 246-250 More about this Journal
Abstract
Colloidal stability of the biodegradable nanoparticle was characterized by measuring the variation of particle size with time using photon correlation spectroscopy. Three kinds of polymers, namely, poly(D,L-lactide-co-glycolide)(PLGA), PLGA/poly(L-lactide) blends, and PLGA/poly(L-lactide)-g-poly(ethylene glycol) blends were used as matrix material for nanoparticle preparation. Nanoparticles were prepared with or without using poly(vinyl alcohol)(PVA) as suspension stabilizer to evaluate the condition of preparation. Nanoparticles from the blend of amphiphilic graft copolymer with short poly(ethylene glycol) chain and PLGA maintained suspension for 1 day when protein stock solution was introduced. This is somewhat improvement in colloidal stability against protein adsorption compared with that of nanoparticles without PEG moiety. Suspension stabilizer, PVA, had a significant effect on the colloidal stability against freezing and protein adsorption which led to coagulation of nanoparticles. It is important to consider effect of suspension stabilizer as well as materials used to prepare nanoparticle on the colloidal stability.
Keywords
nanoparticle; amphiphilic; biodegradable; colloidal stability; particle size;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
Times Cited By Web Of Science : 0  (Related Records In Web of Science)
Times Cited By SCOPUS : 0
연도 인용수 순위
1 K. S. Soppimath, T. M. Aminabhavi, A. R. Kulkarni, and W. E. Rudzinski, J. Control. Release, 70, 1 (2001)   DOI   ScienceOn
2 K. E. Uhrich, S. M. Cannizarro, R. S. Langer, and K. M. Shakesheff, Chem. Rev., 99, 3181 (1999)   DOI   ScienceOn
3 R. Gref, Y. Minamitake, M. T. Peracchia, V. Trubetskoy, V. Torchilin, and R. Langer, Science, 263, 1600 (1994)   DOI
4 B. S. Kim, Y. Zeroual, and K. M. Lee, Polymer(Korea), 31, 20 (2007)   과학기술학회마을   DOI
5 T. K. Jung, Y. M. Oh, and B. C. Shin, Polymer(Korea), 27, 370 (2003)
6 T. Verrecchia, G. Spenlehauer, D. V. Bazile, A. Murry-Brelier, Y. Archimbaud, and M. Veillard, J. Control. Release, 36, 49 (1995)   DOI
7 J. K. Kweon, Y. I. Jeong, M. K. Jang, C. H. Lee, and J. W. Nah, Polymer(Korea), 26, 535 (2002)
8 J. Fu and C. Wu, J. Polym. Sci.; Part B: Polym. Phys., 39, 703 (2001)   DOI   ScienceOn
9 M. van de Weert, J. Hoechstetter, W. E. Hennink, and D. J. A. Crommelin, J. Control. Release, 68, 351 (2000)   DOI   ScienceOn
10 M. F. Zambaux, F. Bonneaux, R. Gref, P. Maincent, E. Dellacherie, M. J. Alonso, P. Labrude, and C. Vigneron, J. Control. Release, 50, 31 (1998)   DOI   ScienceOn
11 K. M. Shakesheff, C. Evora, I. Soriano, and R. Langer, J. Colloid Interface Sci., 185, 538 (1997)   DOI   ScienceOn
12 S. M. Moghimi, A. C. Hunter, and J. C. Murray, Pharmacol. Rev., 53, 283 (2001)
13 H. Murakami, Y. Kawashima, T. Niwa, T. Hino, H. Takeuchi, and M. Kobayashi, Int. J. Pharm., 149, 43 (1997)   DOI   ScienceOn
14 H. Murakami, M. Kobayashi, H. Takeuchi, and Y. Kawashima, Powder Technol., 107, 137 (2000)   DOI
15 K. Y. Cho, K. H. Lee, and J. K. Park, Polym. J., 32, 537 (2000)   DOI   ScienceOn
16 M. F. Zambaux, F. Bonneaux, R. Gref, E. Dellacherie, and C. Vigneron, J. Biomed. Mater. Res., 44, 109 (1999)   DOI   ScienceOn
17 K. Y. Cho, C. H. Kim, J. W. Lee, and J. K. Park, Macromol. Rapid Commun., 20, 598 (1999)   DOI
18 C. Wu, J. Fu, and Y. Zhao, Macromolecules, 33, 9040 (2000)   DOI   ScienceOn
19 R. Gref, A. Domb, P. Quellec, T. Blunk, R. H. Müller, J. M. Verbavatz, and R. Langer, Adv. Drug Deliver. Rev., 16, 215 (1995)   DOI   ScienceOn
20 K. Avgoustakis, A. Beletsi, Z. Panagi, P. Klepetsanis, E. Livaniou, G. Evangelatos, and D. S. Ithakissios, Int. J. Pharm., 259, 115 (2003)   DOI
21 K. Y. Cho, S. H. Choi, C. H. Kim, Y. S. Nam, T. G. Park, and J. K. Park, J. Control. Release, 76, 275 (2001)   DOI   ScienceOn
22 G. Jian, B. H. Woo, F. Kang, J. Singh, and P. P. DeLuca, J. Control. Release, 79, 137 (2002)   DOI
23 A. Vonarbourg, C. Passirani, P. Saulnier, and J. P. Benoit, Biomaterials, 27, 4356 (2006)   DOI   ScienceOn
24 M. J. Santander-Ortega, N. Csaba, M. J. Alonso, J. L. Ortega- Vinuesa, and D. Bastos-Gonzalez, Colloid Surface A, 296, 132 (2007)   DOI
25 S. K. Sahoo, J. Panyam, S. Prabha, and V. Labhasetwar, J. Control. Release, 82, 105 (2002)   DOI   ScienceOn
26 J. Rieger, C. Passirani, J. P. Benoit, K. van Butsele, R. Jerome, and C. Jerome, Adv. Funct. Mater., 16, 1506 (2006)   DOI   ScienceOn