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Photopolymerization and Properties of PCL-Based Biodegradable Molecularly Imprinted Polymers  

Kim, Sun-Hui (Department of Chemical Engineering, Chungbuk National University)
Lee, Kyung-Soo (Department of Chemical Engineering, Chungbuk National University)
Kim, Yong-Hoon (Department of Chemical Engineering, Chungbuk National University)
Choi, Woo-Jin (Department of Chemical Engineering, Chungbuk National University)
Kim, Beom-Soo (Department of Chemical Engineering, Chungbuk National University)
Kim, Eung-Kook (Department of School of Medicine, Chungbuk National University)
Kim, Dae-Su (Department of Chemical Engineering, Chungbuk National University)
Publication Information
Polymer(Korea) / v.31, no.2, 2007 , pp. 153-159 More about this Journal
Abstract
Biodegradable molecularly imprinted polymers (MIPs) can be applied in the biomedical area of biosensors, drug delivery, etc. Therefore, in this study, biodegradable theophylline MIPs were synthesized via photopolymerization using a poly $(\varepsilon-caprolactone)$ (PCL) macromer as a cross-linker and their physical properties were investigated. The yield for the synthesis of the PCL macromer with terminal acrylate groups was ca. 78 mol%. The products were characterized by the combination of FT-IR and $^1H-NMR$ spectroscopic analyses. UV/Visible spectroscopic analysis for removing and rebinding theophylline was performed by monitoring the theophylline concentration in the solution. In vitro biodegradation tests of the theophylline MIPs performed in phosphate buffered saline (PBS) solution at $37^{\circ}C$ showed good biodegradability of the MIPs.
Keywords
biodegradable molecularly imprinted polymers; $poly(\varepsilon-caprolactone)$; theophylline; photopolymerization; biodegradability;
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1 G. Wulff, Angew. Chem. Int. Engl., 34, 1812 (1995)
2 S. A. Piletsky, E.V. Piletska, A. Bossi, K. Karim, P. Lowe, and A. P. F. Turner, Biosens. Bioelectron., 16, 701 (2001)   DOI   ScienceOn
3 B. Andrea, A. Tolokan, G. Horvai, V. Horvath, F. Lanza, A. J. Hall, and B. Sellergren, J. Chromatogr. A, 930, 31 (2001)   DOI   ScienceOn
4 M. J. Yoshikawa, J. Izumi, T. Kitao, and S. Sakamoto, Mscromol., 29, 8197 (1996)
5 G. G. Pitt, M. M. Gratzei, G. L. Kimmei, J. Surles, and A. Schindler, Biomaterials, 2, 215 (1981)
6 D. S. Kim and W. H. Seo, J. Appl. Polym. Sci., 92, 3921 (2004)   DOI   ScienceOn
7 A. J. Domb, J. Kost, and D. M. Wiseman, Handbook of Biodegradable Polymers, Hardwood Academic Publishers, Amsterdam, Netherland, p.70-72 (1997)
8 N. Masque, M. Marce, and F. Borrull, TrAC, 20, 477 (2001)
9 B. S. Kim and K. S. Lee, Kor. Patent 100637683 (2006)
10 H. Y. Kweon, M. K. Yoo, I. K. Park, T. H. Kim, H. C. Lee, H. S. Lee, J. S. Oh, T. Akaike, and C. S. Cho, Biomaterials, 24, 801 (2003)   DOI   ScienceOn
11 M. J. Yoshikawa, J. Izumi, and T. Kitao, Chem. Lett., 8, 611 (1996)
12 S. C. Woodward, P. S. Brewer, and F. Moatamed, J. Biomed. Mater. Res., 44, 437 (1985)
13 P. D. Darney, S. E. Moroe, C. M. Klaisle, and A. Alvarado, Am. J. Obstet. Gynecol., 160, 1292 (1989)
14 S. H. Cheong, C. Y. Oh, J. I. Seo, and J. K. Park, Korean J. Biotechnol. Bioeng., 16,115 (2001)
15 S. H. Cheong, M. G. Suh, J. K. Park, and I. Karube, J. Kor. Ins. Chem. Eng., 36, 1, 27 (1998)
16 G. Wulff, Molecular Interactions in Bioseperstions, T. Ngo, Editor, Plenium Press, New York, p.363 (1993)
17 R. J. Ansell, D. Kriz, and F. Borrull, Curr. Opin. Biotechnol., 7, 89 (2001)
18 J. M. Hong, P. E. Andersson, J. Qian, and C. R. Martin, Chem. Msster., 10, 1029 (1998)
19 M. Kamiyama, T. Takeuchi, T. Mukawa, and H. Asanuma, Molecular Imprinting from Fundamentals to Applications, Wiley- VCH, Weinheim, p.12 (2003)
20 J. Matsui, I. A. Nicholls, and T. Takeuchi, Analytica Chimica Acta., 365, 89 (1998)
21 G. Ciardeli, B. Cioni, C. Cristallini, N. Barbani, D. Silvestri, and P. Giusti, Biosens. Bioelectron., 20, 1083 (2004)   DOI   ScienceOn
22 D. Kriz and K. Mosbach, Anal. Chim. Acta., 300, 71 (1994)
23 J. Mathew-Krotz and K. J. Shea, J. Am. Chem. Soc., 118, 8154 (1996)
24 K. S. Lee, D. S. Kim, and B. S. Kim, 'Biodegradable Molecularly Imprinted Polymers', Biotechnol, Bioproc. Eng., in press
25 R. S. Bezwada, D. D. Jamiolkowski, I. Y. Lee, V. Agarwal, J. Persival, S. Treka-Benthin, M. Erneta, J. Suryadevara, A. Yang, and S. Liu, Biomaterials, 16, 1141 (1995)
26 M. J. Yoshikawa, J. Izumi, and T. Kitao, Polym. J., 29, 205 (1997)   DOI   ScienceOn