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Synthesis and Characterization of Amphiphilic Polyurethanes as Coating Materials for Urinary Catheters  

Park Jae-Hyung (College of Environment and Applied Chemistry, Kyung Hee University)
Kim Kwang-Meyung (Biomedical Research Center, Korea Institute of Science and Technology)
Chung Hes-Son (Biomedical Research Center, Korea Institute of Science and Technology)
Kwon Ick-Chan (Biomedical Research Center, Korea Institute of Science and Technology)
Bae You-Han (Department of Pharmaceutics & Pharmaceutical Chemistry, University of Utah)
Jeong Seo-Young (Department of Pharmaceutics, College of Pharmacy, Kyung Hee University)
Publication Information
Polymer(Korea) / v.30, no.3, 2006 , pp. 247-252 More about this Journal
Abstract
The long-term use of indwelling urinary catheters can allow bacterial adhesion to their surfaces, followed by the catheter-associated urinary tract infection. In an attempt to minimize the bacterial adhesion, various amphiphilic polyurethanes (APUs) were synthesized as potential coating materials for urinary catheters. By varying composition of the soft segments such as PEO, PTMO, and PDMS, four different polyurethanes were synthesized. All the APU-coated urinary catheters had the smooth surfaces and showed higher hydrophilicity, compared to the commercial silicone catheters. In particular, the use of APUs with the higher PEG content significantly augmented hydrophilicity and remarkably reduced the total amount of bacteria adhering to the surface. Overall, the APUs prepared in this study provided the promising potential as coating materials for urinary catheters.
Keywords
amphiphilic polyurethane; urinary catheter; bacterial adhesion; poly (ethylene oxide);
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