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Optimal Hydrophilization and Chondrocyte Adhesion of PLLA Films and Scaffolds by Plasma Treatment and Acrylic Acid Grafting  

Yang Hee-Seok (Biomaterials Research Center Korea Institute of Science and Technology, Department of Chemical Engineering, Hanyang University)
Park Kwi-Deok (Biomaterials Research Center Korea Institute of Science and Technology)
Ahn Kwang-Duk (Biomaterials Research Center Korea Institute of Science and Technology)
Kim Byung-Soo (Department of Chemical Engineering, Hanyang University)
Han Dong-Keun (Biomaterials Research Center Korea Institute of Science and Technology)
Publication Information
Polymer(Korea) / v.30, no.2, 2006 , pp. 168-174 More about this Journal
Abstract
To utilize as highly functional scaffolds for tissue engineering by improving hydrophobicity and cell compatibility of the exist polymer scaffolds, the biodegradable poly(L-lactic acid) (PLLA) films and scaffolds having the optimal hydrophilicity were prepared by in situ plasma treatment and grafting of a carboxyl acid-containing monomer, acrylic acid (AA) in the chamber. From the results of surface analyses, surface-modified nonporous PLLA film and dual pore scaffold surfaces showed high hydrophilicity due to the decrease in contact angle and the increase in carboxylic groups as compared with untreated PLLA control. In particular, among various surface modification methods, Ar(argon)+AA+AA sample prepared by Ar plasma and then acrylic acid treatments displayed lower contact angle and more carboxylic groups thar Ar/AA and Ar+TP(thermal polymerization) samples, indicating that Ar+AA+AA sample was optimally treated for improving its hydrophilicity. In the cases of surface modified nonporous PLLA films and dual pore scaffolds, the adhesion and proliferation of chondrocytes increased with increasing their hydrophilicity.
Keywords
tissue engineering; biodegradable scaffolds; plasma treatment; acrylic acid grafting; hydrophilization; chondrocyte adhesion;
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