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The Effects of Osmogant and Binder in Membrane on Nifedipine Release from Osmotic Granule  

Jeong Sung-Chan (Department of Polymer Engineering, Pukyung University)
Cho Young-Ho (Department of Advanced Organic Materials Engineering, Chonbuk National University)
Kim Moon-Suk (NanoBiomaterials Laboratory, Korea Research of Chemical Technology)
Lee Bong (Department of Polymer Engineering, Pukyung University)
Khang Gil-Son (Department of Advanced Organic Materials Engineering, Chonbuk National University, NanoBiomaterials Laboratory, Korea Research of Chemical Technology)
Rhee John-M. (Department of Advanced Organic Materials Engineering, Chonbuk National University)
Lee Hai-Bang (Department of Advanced Organic Materials Engineering, Chonbuk National University, NanoBiomaterials Laboratory, Korea Research of Chemical Technology)
Publication Information
Polymer(Korea) / v.30, no.2, 2006 , pp. 112-117 More about this Journal
Abstract
To improve the type error of osmotic tablet which is one of the drug delivery system, osmotic granule could be manufactured by fluidized bed coating. It has drug layer containing different amount of osmogant and is coated with membrane including different types of binder. We confirmed that the morphology of osmotic granule was different at each coating step. The more mont of osmotic agent, the faster drug release was observed due to increasing the driving force for drug release from osmotic granule. And drug release from osmotic granule coated with membrane using different types of binder was differed by solubility of binders to water. The formation of pore in membrane was confirmed by SEM and DSC Membrane using water soluble binder released more amount of drug. From these results, we assured that difference of osmotic pressure between the inside and the outside of granule and porosity of membrane have an effect on drug release from osmotic granule.
Keywords
osmotic drug delivery system; granulation; fluidized bed coating; semipermeable membrane;
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