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Synthesis and Characterization of Biodegradable MethoxyPoly(ethylene glycol)-Poly$(\varepsilon-caprolactone-co-L-lactide)$ Block Copolymers  

Hyun Hoon (Department of Advanced Organic Materials Engineering, Chonbuk National University)
Cho Young Ho (Department of Advanced Organic Materials Engineering, Chonbuk National University)
Jeong Sung Chan (Department of Polymer Engineering, Pukyung National University)
Lee Bong (Department of Polymer Engineering, Pukyung National University)
Kim Moon Suk (Nanobiomaterials Laboratories, Korea Research Institute of Chemical Technology)
Khang Gilson (Department of Advanced Organic Materials Engineering, Chonbuk National University)
Lee Hai Bang (Nanobiomaterials Laboratories, Korea Research Institute of Chemical Technology)
Publication Information
Polymer(Korea) / v.30, no.1, 2006 , pp. 28-34 More about this Journal
Abstract
A series of methoxypoly(ethylene glycol) $(MPEG)-poly(\varepsilon-co-L-lactide)$ (PCLA) diblock copolymers were synthesized by ring-opening polymerization of a mixture of $\varepsilon-caprolactone$ and L-lactide with different ratios in the presence of $Sn(Oct)_2$. The characterization of MPEG-PCLA diblock copolymers were examined by $^1H-NMR$, GPC, DSC, and XRD. Kinetic study on ring-opening polymerization of monomer mixtures was carried out in various conditions such as a variation with polymerization time, amount of catalyst, and temperature. The highest conversion obtained in 1.2 ratic of initiator venn catalyst at $110\;^{\circ}C$. The biodegradable characterization of MPEG-PCLA diblock copolymers in aqueous solution was carried out by using GPC for $1\~14$ weeks. The biodegradability of MPEG-PCLA diblock copolymers increased as the L-lactide content of diblock copolymers increased. In conclusion, we confirmed the dependence of polymerization rate according to various conditions. In addition, we can control the biodegradability of MPEC-PCLA diblock copolymers by changing the ratio of PCL and PLA block segment.
Keywords
MPEG-PCLA; L-lactide; ring-opening polymerization; kinetics; biodegradability;
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