Browse > Article

Synthesis and Characteristics of Hyaluronic Acid Bead Crosslinked by 1,3-Butadiene diepoxide  

Kwon, Ji-Young (Department of Chemical Engineering and Nano-Bio Technology, Hannam University)
Cheong, Seong-Ihl (Department of Chemical Engineering and Nano-Bio Technology, Hannam University)
Publication Information
Polymer(Korea) / v.29, no.5, 2005 , pp. 445-450 More about this Journal
Abstract
Hyaluronic acid-based beads were prepared in order to develop a biomedical material for augumentation. Hyaluronic acid was crosslinked by 1,3-butadiene diepoxide in a suspension state maintained by rapid mixing of soybeen oil and hyaluronic acid solution. The particle size, surface area and swelling ratio were measured to investigate the physical properties of the synthesized beads and the bead surface was examined by scanning electron microscopy. The beads were formed in the range of $5-12vol\%$ concentration of crosslinking agent, which showed monodisperse size distribution. Both BET surface area and swelling ratio decreased as the concentration of either hyaluronic acid or crosslinking agent increased, and crosslinking temperature decreased. Bead size could be effectively controlled by mixing speed without affecting other physical property.
Keywords
hyaluronic acid; 1,3-butadiene diepoxide; bead; crosslinking; size control;
Citations & Related Records

Times Cited By Web Of Science : 1  (Related Records In Web of Science)
Times Cited By SCOPUS : 0
연도 인용수 순위
  • Reference
1 G. Khang, M. S. Kim, S. H. Cho, H. B. Lee, J. H. Chang, and K. J. Kim, Polym. Sci. and Tech., 14,431 (2003)
2 F. Lim and A. M. Sun, Science, 210, 908 (1980)   DOI
3 S. P. Zhong, D. Campoccia, P. J. Doherty, R. L. Benedetti, and D. F. Williams, Biomaterials, 15, 359 (1994)   DOI   ScienceOn
4 H. S. Nam, J. H. Kim, J. H. An, and D. J. Chung, Polymer(Korea), 25, 476 (2001)
5 J. Aigner, J. Tegeler, P. Hutzler, D. Campoccia, A. Pavesio, and C. Hammer, J. Biomed. Mater. Res., 42, 172 (1998)   DOI   ScienceOn
6 C. Ouwerx, N. Velings, M. M. Mestdagh, and M. A. V. Axelos, Polymer Gels and Networks, 6, 393 (1998)   DOI   ScienceOn
7 O. Wichterle and D. Lim, Nature, 185,117 (1960)   DOI
8 H. Clayton, R. James, and N. London, Acta. Diabetol., 30, 181 (1993)   DOI   ScienceOn
9 G. D. Prestwiteh, D. M. Marecak, and J. F. Marecek, J. Control. Release, 53, 93 (1998)   DOI
10 L. Benedetti, R. Cortivo, T. Berti, A. Berti, F. Pea, M. Marzzo, M. Moras, and G. Abatangelo, Biomaterials, 14, 1154 (1993)   DOI   ScienceOn
11 E. Akertek and L. Tarhan, Appl. Biochem. Technol., 50, 291 (1995)   DOI   ScienceOn
12 M. Chiou and H. Li, J. Hazardous Materials, B93, 233 (2002)
13 L. Zhang, G. Cheng, and C. Fu, Reactive & Functional Polymers, 56,167 (2003)   DOI   ScienceOn
14 Y. Tokita and A. Pkamoto, Eur. Polym. J., 32, 1011 (1996)   DOI   ScienceOn
15 S. Park, H. J. Lee, K. H. Lee, and H. Suh, Biomaterials, 24,1631 (2003)   DOI   ScienceOn
16 J. A. Hunt, H. N. Joshi, V. J. Stella, and E. M. Topp, J. Control. Release, 12, 159 (1990)   DOI   ScienceOn
17 W. S. W. Ngah, C. S. Endud, and R. Mayanar, Reactive & Functional Polymers, 50, 181 (2002)   DOI   ScienceOn
18 G. Palmierie, P. Giardina, and B. Desiderio, Enzyme Microbiol. Biotechnol., 16,151 (1994)   DOI   ScienceOn
19 S. Park, J. Park, H. O. Kim, M. J. Song, and H. Suh, Biomaterials, 22, 1205 (2002)
20 K. A. Gomez and A. A. Gomez, Statistical Procedures for Agricultural Research, 2nd ed., John Wiely and Sons, New York, 1984
21 N. A. Peppas, Hydrogels in Medicine and Pharmacy, Boca Raton, Vol. I, II, III, CRC Press Inc., Florida, 1986
22 Y. Luo, K. R. Kirker, and G. D. Prestwich, J. Control. Release, 69, 169 (2000)   DOI   ScienceOn
23 P. A. Delco, M. Stefanetti, D. Pressato, S. Piana, M. Dona, and A. Pavesio, Fertil. Steril., 69, 318 (1998)   DOI   ScienceOn
24 T. Murakata, H. Honma, S. Nakazato, and Kuroda, J. Chem Eng. Japan, 34, 299 (2001)   DOI   ScienceOn
25 S. Declerck, D. Strullu, and C. Plenchette, J. Biotechnol., 48, 51 (1996)   DOI
26 F. Rodriguez, Principles of Polymer Systems, 3rd ed, Hemisphere Publishing Co., New York, 1989