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The Effect of Bead Size and Drug Solubility on Drug Release from Osmotic Granule Delivery System for Nifedipine  

Jeong Sung Chan (Department of Polymer Engineering, Pukyung National University)
Chon Se Kang (Department of Advanced Organic Materials Engineering, Chonbuk National University)
Jo Young Ho (Department of Advanced Organic Materials Engineering, Chonbuk National University)
Kim Moon Suk (Nanobiomaterials Laboratory, Korea Research Institute of Chemical Technology)
Lee Bong (Department of Polymer Engineering, Pukyung National University)
Khang Gilson (Department of Advanced Organic Materials Engineering, Chonbuk National University, Nanobiomaterials Laboratory, Korea Research Institute of Chemical Technology)
Lee Hai Bang (Department of Advanced Organic Materials Engineering, Chonbuk National University, Nanobiomaterials Laboratory, Korea Research Institute of Chemical Technology)
Publication Information
Polymer(Korea) / v.29, no.3, 2005 , pp. 288-293 More about this Journal
Abstract
Osmotic granule system which is one of the drug delivery systems has been developed to improve manufacturing process and other problems of tablet osmotic systems. It consists of water swellable seed layer, nifedipine drug layer, and drug release controlled membrane layer and manufactured by fluidized bed coater. The granule size and mombrane thickness can be controlled by various amounts of seed and coating solution, respectively. It could be observed that the morphology of osmotic granule was different at each coating step as well as type of coating solution. The bigger the size of granule, the slower the release rate was observed due to decreasing the total specific surface wed of granule. Also, it was observed that the increase of membrane thickness was caused to retard the dissolution of nifedipine due to decreasing the water absorption rate. The drug solubility for dissolution media is greatly affected to nifedipine release. From these results, we assured that osmotic granule can be fabricated by fluidized bed coating methods, and the appropriate release profile could be controlled by the controlling of bead size, membrane thickness and dissolution media.
Keywords
osmotic drug delivery system; granulation; fluidized bed coating;
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연도 인용수 순위
1 G. Khang, J. M. Rhee, and H. B. Lee, 'Drug Delivery System Using Osmotic Pump', in High Efficiency Anticancer Drug Using Polymeric Biomaterials, H. B. Lee, Editor, Munundang Publishing Co., Seoul, Chap. 10, pp 135-154 (2004)
2 G. Khang and H. B. Lee, Biomedical Polymers, Korean Chemical Society Press, Munundang, Seoul, Korea, 2001
3 G. Khang, J. Ku, B. Lee, and H. B. Lee, Biomater. Res., 4, 20 (2000)
4 D. H. Lee, G. Khang, and H. B. Lee, Biomater. Res., 5, 1 (2001)
5 F. Theeuwes and T. Higuchi, U.S. Patent 3,845,770 (1972)
6 P. Rama Rao and P.V. Diwan, Pharm. Acta Helv., 72, 47 (1997)   DOI   ScienceOn
7 F. W. Goodhart, M. R. Harris, K. S. Murthy, and R. U. Nesbitt, Pharm. Technol., 8, 64 (1984)
8 M. Takahashi, M. Mochizuki, T. Itoh, and M. Ohta, Chem. Pharm. Bull., 42, 333 (1994)   DOI   ScienceOn
9 A. Wade and P. J. Weller (Eds.), Handbook of Pharmaceutical Excipients, Am. Pharm. Assoc., Washington DC, 1994
10 M. M. Meier, L. A. Kanis, and V. Soldi, Int. J. Pharm., 278, 99 (2004)   DOI   ScienceOn
11 H. S. A. Auda, T. A. Najjar, K. I. Al-Khamis, B. M. Al-Hadiya, N. M. Ghilzai, and N. F. Al-Fawzan, J. Pharm. Biomed. Anal., 22, 241 (2000)   DOI   ScienceOn
12 I. Niopas and A. C. Dafrsios, J. Pharm. Biomed. Anal., 32, 1213 (2003)   DOI   ScienceOn
13 H. Ho, C. Chen, and M. Sheu, J. Control. Rel., 68, 433 (2000)   DOI   ScienceOn
14 L. Liu, G. Khang, J. M. Rhee, and H. B. Lee, Biomater. Res., 3, 47 (1999)
15 H. Kage, R. Abe, R. Hattanda, T. Zhou, H. Ogura, and Y. Matsuno, Powder Technol., 130, 203 (2003)   DOI
16 P, Colombo, R. Bettimi, G. Massimo, P. L. Catellani, P. Santi, and N. A. Peppas, J. Pharm. Sci., 84, 991 (1995)   DOI   ScienceOn
17 B. K. Kang, G. Khang, J. M. Kim, S. Y. Jeung, H. B. Lee, and S. H. Cho, J. Korean Pharm. Sci., 33, 179 (2003)
18 E. C. Feleder, M. Befumo, M. A. Ricci, Coppari, and J. Faour, Clin. Pharmacol. Therap., 75, PI-41 (2004)
19 F. Theeuwes, Novel Drug Delivery Systems, ADIS Press, 157 (1981)
20 P. S. L. Wong, B. L. Barclay, J. C. Deters, and F. Theeuwes, U.S. Patent 4,765,989 (1986)
21 P. S. Shah and J. L. Zatz, Drug. Dev. Ind. Pharm., 18, 1759 (1992)   DOI
22 Y. Wang and M. A. Winnik, Macromol., 23, 4731 (1990)   DOI
23 P. D. Henry, Am. J. Cardiol., 46, 1047 (1980)   DOI   ScienceOn
24 F. Theeuwes, J. Pharm. Sci., 64, 1987 (1975)   DOI
25 P. B. Deast, Microencapsulation and Related Drug Processes, Marcel Dekker, New York, 1984
26 J. C. Gutierrez-Rocca and J. W. McGinity, Int. J. Pharm., 103, 293 (1994)   DOI   ScienceOn
27 M. R. Harris, I. Ghebre-Sellassie, and R. U. Nesbitt, Pharm. Technol., 10, 102 (1986)
28 M. Donbrow(Ed.), Microencapsulation and Nanoparticles in Medicine and Pharmacy, CRC Press, Boca Raton, FL, 1991
29 H. B. Lee, D. H. Lee, B. K. Kang, S. Y. Jeung, and G. Khang, J. Korean Pharm. Sci., 32, 241 (2002)
30 F. Theeuwes, Pharm. Int., 5, 293 (1984)
31 R. C. Rowe, Int. J. Pharm., 29, 37 (1986)   DOI   ScienceOn
32 I. Niopas and and A. C. Daftsios, J. Pharm. Biomed. Anal., 32, 1213 (2003)   DOI   ScienceOn
33 L. Liu, G. Khang, J. M. Rhee, and H. B. Lee, Korea Polym. J., 7, 289 (1999)
34 J. S. Grundy and R. T. Foster, Clin. Pharmacokinet., 30, 28 (1996)   DOI   ScienceOn
35 L. Liu, G. Khang, J. M. Rhee, and H. B. Lee, J. Control. Rel., 67, 309 (2000)   DOI
36 J. Siepmann, F. Lecomte, and R. Bodmeirer, J. Control. Rel., 60, 379 (1999)   DOI   ScienceOn
37 T. U. Okarter and K. Singla, Drug. Dev. Ind. Pharm., 26, 323 (2000)   DOI   ScienceOn
38 R. C. Rowe, A. D. Kotaras, and E. F. T. White, Int. J. Pharm., 22, 57 (1984)   DOI   ScienceOn
39 L. Lui, G. Khang, J. M. Rhee, and H. B. Lee, Acta Pharm. Sinica, 38, 620 (2003)
40 L. Lui, Q. Xu, G. Khang, J. M. Rhee, and H. B. Lee, Acta Pharm. Sinica, 38, 966 (2003)
41 M. F. Saettone, G. Perini, P. Rijli, L. Rodriguez, and M. Cini, Int. J. Pharm., 126, 83 (1995)   DOI
42 L. Liu, J. Ku, G. Khang, B. Lee, J. M. Rhee, and H. B. Lee, J. Control. Rel., 68, 145 (2000)   DOI   ScienceOn
43 L. Liu, G. Khang, J. M. Rhee, and H. B. Lee, Bio-Med. Mater. Eng., 9, 297 (1999)