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Preparation and Characterization of BICND-loaded Multi-Layer PLGA Wafer Containing Glycolide Monomer  

채강수 (전북대학교 유기신물질공학과)
이진수 (전북대학교 유기신물질공학)
정제교 (삼천당제약 중앙연구)
조선행 (한국화학연구원 나노생체재료고분자)
이해방 (한국화학연구원 나노생체재료고분자)
강길선 (전북대학교 유기신물질공학과)
Publication Information
Polymer(Korea) / v.28, no.4, 2004 , pp. 335-343 More about this Journal
Abstract
Carmustine (l,3-bis(2-chloroethyI)-1-nitrosourea, BICNU) used as antineoplastic drug for the treatment of brain tumor is not appropriate for the long term delivery, because it has short biological half life. Therefore, poly(D,L-lactide-co-glycolide) (PLGA) is useful as drug carrier for the long term delivery due to bulk erosion property. Glycolide monomer is applied to release of BICNU owing to non-toxic and monomeric components after biodegradation of PLGA. In this study, BICNU-loaded PLGA wafers with or without glycolide monomer were fabricated by conventional direct compression method for the sustained release of BICNU. These wafers were observed for their release profiles of BICNU and degradation rates by SEM, NMR, and GPC. Furthermore, we make multi-layer wafers and compare them with release profiles of conventional wafer. From these results, drug release of BICNU-loaded PLGA wafers was increased with increasing the glycolid monomer contents. We confirmed that glycolide monomer and BICNU contents in barrier-layer influenced the drug release profiles and degradation rate.
Keywords
BICNU; PLGA wafer; glycolide monomer; zero-order profile;
Citations & Related Records

Times Cited By Web Of Science : 6  (Related Records In Web of Science)
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