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Preparation and Characterization of Sponge Using Porcine Small Intestinal Submucosa  

신혜원 (전북대학교 유기신물질공학과)
김선화 (전북대학교 유기신물질공학과)
장지욱 (전북대학교 유기신물질공학과)
김문석 (한국화학연구원 나노생체재료연구팀)
조선행 (한국화학연구원 나노생체재료연구팀)
이해방 (한국화학연구원 나노생체재료연구팀)
강길선 (전북대학교 유기신물질공학과)
Publication Information
Polymer(Korea) / v.28, no.2, 2004 , pp. 194-200 More about this Journal
Abstract
Porcine small intestine submucosa (SIS) has been widely used as a biomaterial without immunorejection responses. Crosslinked SIS sponges were characterized for the possibility of the bio-interactive wound dressings and tissue engineered scaffolds. SIS powders were dissolved in 3% acetic acid aqueous solution at 48hrs followed by pouring into mold and then fabricated by freeze-drying method. SIS sponge was prepared by crosslinked with 1-ethyl-(3-3-dimethyl aminopropyl) carbodiimide hydrochloride (EDC) solution (deionized water: ethanol=5:95) with 1-100mM concentration for 24 hrs and Iyophilized. SIS sponges were characterized by scanning electron microscopy, differential scanning calorimeter, and Fourier transform infrared spectrometer and were tested their porosity and water absorption ability. It was observed that the concentration of EDC might be exceeded 50 mM to get good physical characteristics. In conclusion, it seems that SIS sponge could be very useful for the applications of wound healing and tissue construction.
Keywords
small intestinal submucosa; sponge; collagen; wound dressing; crosslinking;
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