Browse > Article

Transdermal Drug Release of Polymer Matrix of Unsaturated Poly(3-hydroxyalkanoate)  

이수홍 (한국화학연구원 화학소재연구부)
신병철 (한국화학연구원 화학소재연구부)
이영하 (충남대학교 미생물학과)
김형우 (충남대학교 미생물학과)
김영백 (배재대학교 고분자공학과)
김승수 (한국화학연구원 화학소재연구부)
Publication Information
Polymer(Korea) / v.27, no.6, 2003 , pp. 536-541 More about this Journal
Abstract
Unsaturated poly(3-hydroxyalkanoate) (UPHA) was biosynthesized and the properties of drug delivery using the polymer matrix were investigated. The biosynthesis of UPHA was carried out by pH-stat fed batch fermentation of Pseudomonas oleovorans (ATCC 29347) grown solely with 10-undecenoic acid as a carbon source. The physical and chemical properties of the biosynethesized UPHA were characterized using NMR, FT-IR, GPC and DSC. The drug release experiments were carried out using HPLC with a diffusion cell fur the release amount of ketoprofen as model drug. The effects of crosslinking degree, patch thickness, and enhancer on the drug release were studied. The drug release rate was linearly decreased and consistent with increased crosslinking degree of the polymer matrix. The duration of drug release was enhanced by the Increased patch thickness. The drug release rate was increased with increased amount of propylene gylcol as an enhancer.
Keywords
unsaturated poly(3-hydroxyalkanoate); drug delivery; transdermal; ketoprofen;
Citations & Related Records

Times Cited By Web Of Science : 1  (Related Records In Web of Science)
Times Cited By SCOPUS : 0
연도 인용수 순위
  • Reference
1 /
[ C.W.Pouton;S.Akhtar ] / Adv. Drug Del. Rev.   DOI   ScienceOn
2 /
[ G.W.Haywood;A.J.Anderson;L.Chu;E.A.Dawes ] / Biochem. Soc. Trans.
3 /
[ G.Odham;A.Runlid;G.Westerdahl;P.Marden ] / Appl. Environ. Microbiol.
4 /
[ L.L.Wallen;W.K.Rohwedder ] / Environ. Sci. Technol   DOI   ScienceOn
5 /
[ D.Y.Kim;Y.B.Kim;Y.H.Rhee ] / Macromolecules   DOI   ScienceOn
6 /
[ A.Steinbuchel;H.E.Valentin ] / FEMS. Micobiol. Lett.   DOI
7 /
[ R.H.Findlay;D.C.White ] / Appl. Environ. Microbiol.
8 /
[ C.Alving;R.W.Baker;D.Chapman;A.T.Florence;R.Langer;K.Larsson;L.P.Luigi ] / Controlled Release of Drugs: Polymers and Aggregate Systems
9 /
[ T.Suzuki;W.L.Zahler;E.W.Emerich ] / Arch. Biochem. Biophys.   DOI   ScienceOn
10 /
[ A.J.Anderson;E.A.Dawes ] / Micobio. Rev.
11 /
[ D.Y.Kim;Y.B.Kim;Y.H.Rhee ] / Macromolecules   DOI   ScienceOn
12 /
[ H.S.Lee;J.S.Lee;J.S.Yoon;H.J.Choi;S.J.Choi ] / Polymer (Korea)
13 /
[ Y.Poirier;C,Nawrath;C.Somerville ] / Biotechnology   DOI   ScienceOn
14 /
[ E.A.Dawea;P.J.Senior ] / Adv. Microb. Physiol.   DOI