Browse > Article

In Vitro Antitumor Activity of BCNU-Loaded PLGA Wafer Containing Additives  

Lee, Jin-Soo (Department of Advanced Organic Materials Engineering, Chonbuk National University)
An, Tae-Kun (Department of Advanced Organic Materials Engineering, Chonbuk National University)
Shin, Phil-Kyung (Department of Polymer Engineering, Pukyong National University)
Chae, Ghang-Soo (Department of Advanced Organic Materials Engineering, Chonbuk National University)
Jeong, Je-Kyo (Research Center, Samchundang Pharm. Co. Ltd.)
Lee, Bong (Department of Advanced Organic Materials Engineering, Chonbuk National University)
Cho, Sun-Hang (Biomaterials Laboratories, Korea Research Institute of Chemical Technology)
Khang, Gil-Son (Department of Advanced Organic Materials Engineering, Chonbuk National University)
Lee, Hai-Bang (Biomaterials Laboratories, Korea Research Institute of Chemical Technology)
Publication Information
Polymer(Korea) / v.27, no.3, 2003 , pp. 217-225 More about this Journal
Abstract
We fabricated the 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU, carmustine)-loaded PLGA wafers containing poly(N-vinylpyrrolidone) (PVP) or tedium chloride (NaCl) in order to control the release profile of drug in special shape (3 in diameter, 1 mm in thickness) by direct compression method. In vitro release profiles of BCNU could be controlled by additives contained in the wafers. Initial release amount, release rate and duration of BCNU could be controlled with presence of PVP or NaCl. In vitro antitumor activity accessed using 9L gliosarcoma cell line has been evaluated by assaying the viability of cells treated with BCNU released from the wafers containing additives resulting in continuous growth inhibition of 9L gliosarcoma tumor cells. Specially, the continuous growth inhibition of BCNU-loaded PLGA wafers containing additives was more effective than that of non-additive BCNU-loaded PLGA wafers. The cytotoxic effect of the drug from the wafers containing NaCl as compared to wafers containing PVP was more enhanced.
Keywords
brain tumor; BCNU; PLGA wafer; additives; 9L gliosarcorma cells;
Citations & Related Records

Times Cited By Web Of Science : 4  (Related Records In Web of Science)
Times Cited By SCOPUS : 1
연도 인용수 순위
1 /
[ K.Fredrikson;P.Lundgren ] / Acta Pharm.Scand
2 /
[ T.L.Loo;R.L.Dion;R.L.Dixon;D.P.Rall ] / J. Pharm. Sci.   DOI
3 /
[ K.P.Chowdary;K.V.Ramesh ] / Indian Drugs
4 /
[ S.J.Lee;G.Khang;Y.M.Lee;H.B.Lee ] / J. Biomater. Sci. Polym. Ed.   DOI   ScienceOn
5 /
[ T.K.An;H.J.Kang;J.S.Lee;H.S.Seong;J.K.Jeong;G.Khang;Y.K.Hong;H.B.Lee ] / Polymer(Korea)
6 /
[ G.Khang;J.C.Cho;J.W.Lee;J.M.Rhee;H.B.Lee ] / Bio-Med. Master. Eng.
7 /
[ H.B.Lee;G.Khang;J.C.Cho;J.M.Rhee;J.S.Lee ] / Polymer Preprints
8 /
[ G.Khang;J.H.Lee;J.W.Lee;J.C.Cho;H.B.Lee ] / Korea Polymer J
9 /
[ P.Shivanand;O.L.Sprockel ] / Int. J. Pharm.
10 /
[ G.Khang;J.H.Lee;H.B.Lee ] / Polymer Sci. Tech.
11 /
[ S.Trikkonen;PlParonen ] / Int. J. Pharm.   DOI
12 /
[ C.McDonald;C.Richardson ] / J. Pharmacol.   DOI
13 /
[ W.Dang;T.Daviau;P.Ying;Y.Zhao;D.Nowotnik;C.S.Clow:B.Tyler;H.Brem ] / J. Control. Rel.   DOI   ScienceOn
14 /
[ S.A.Seo;H.S.Choi;G.Khang;J.M.Rhee;H.B.Lee ] / Int. J. Pharm.   DOI
15 /
[ T.K.An;H.J.Kang;D.S.Moon;J.S.Lee;H.S.Seong;J.K.Jeong;G.Khang;H.B.Lee ] / Polymer(Korea)
16 /
[ M.Iwata;H.Ueda ] / Drug. Dev. Ind. pharm.   DOI   ScienceOn
17 /
[ E.P.Sipos;B.Tyler;S.Piantadosi;P.C.Burger;H.Brem ] / Cancer Chemother. Pharmacol.   DOI   ScienceOn
18 /
[ S.A.Seo;H.S.Choi;G.Khang;J.M.Rhee;H.B.Lee ] / Macromol. Res.   DOI   ScienceOn
19 /
[ P.Sampath;H.Brem ] / Cancer Control   DOI
20 /
[ I.S.Moussa;L.H.Cartilier ] / Int. J. Pharm.   DOI   ScienceOn
21 /
[ P.Paoletti;G.Hollenbeck;H.Brem;S.Grossman;M.Clovin;R.Langer ] / J. Neurosurg. Sci.
22 /
[ H.Brem;S.Piantadosi;P.Burger;M.Walker;R.Selker;N.Vick;K.Black;M.Sisti;S.Brem;G.Mohr;P.Muller;R.Morawetz;S.Schold ] / Lancet   DOI
23 /
[ H.S.Seong;D.S.Moon;G.Khang;H.B.Lee ] / Macromol. Chem. Symp
24 Synthesis and Properties of Biodegradable Lactic/Glycolic Acid Polymers /
[ X.S.Wu;Wise(et al.)(ed.) ] / Encyclopedic Handbook of Biomaterials and Bioengineering
25 /
[ T.L.Loo;R.L.Dion;R.L.Dixon;D.P.Rall ] / J. Pharm. Sci.   DOI
26 /
[ H.S.Seong;D.S.Moon;G.Khang;H.B.Lee ] / Polymer(Korea)
27 /
[ W.I.Son;D.I.Yun;G.Khang;B.S.Kim;H.B.Lee ] / Biomater.Res.
28 /
[ S.A.Seo;H.S.Choi;D.H.Lee;G.Khang;J.M.Rhee;H.B.Lee ] / Polymer(Korea)
29 /
[ C.S.Reinhard;M.L.Randomsky;W.M.Saltzman;J.Hilton;H.Brem ] / J. Control. Rel.   DOI   ScienceOn
30 /
[ D.F.Emerich;S.R.Winn;Y.Hu;J.Marsh;P.Snodgrass;D.LaFreniere;T.Wiens;B.P.Hasler;R.T.Bartus ] / Pharm.Res.   DOI   ScienceOn
31 /
[ H.J.Kim;I.S.Park;H.J.Lim ] / Korean J. Otolaryngol.
32 /
[ T.K.An;J.S.Lee;S.H.Cho;G.Khang;J.M.Rhee;H.B.Lee ] / Macromol. Chem. Symp.
33 /
[ G.Khang;I.Lee;J.M.Rhee;H.B.Lee ] / Polymer Sci. Tech.
34 /
[ M.Chasin;G.Hollenbeck;H.Brem;S.Grossman;M.Colvin;R.Langer ] / Drug Dev. Ind. Pharm.   DOI
35 /
[ W.G.Lu;Y.Zhang;Q.M.Xiong;Y.C.Bao;Q.H.Chen ] / Chin Pharm.j.
36 /
[ S.Leigh;J.E.Carless;B.W.Burt ] / J. Pharm. Sci.   DOI
37 /
[ H.S.Choi;S.W.Kim;D.I.Yun;G.Khang;J.M.Rhee;Y.S.Kim;H.B.Lee ] / Polymer(Korea)
38 /
[ S.Trikkonen;P.Paronen ] / Int. J. Pharm.   DOI
39 /
[ J.C.Cho;G.Khang;H.S.Choi;J.M.Rhee;H.B.Lee ] / Polymer(Korea)
40 /
[ D.S.Moon;G.Khang;H.S.Seong;J.M.Rhee;J.S.Lee;H.B.Lee ] / Biomaster. Res.
41 /
[ H.S.Choi;G.Khang;H.Shin;J.M.Rhee;H.B.Lee ] / Int.J.Pharm.   DOI
42 /
[ G.Khang;I.Jo;J.H.Lee;I.Lee;H.B.Lee ] / Polymer Sci. Tech.
43 /
[ M.B.Yang;R.J.Tarmargo;H.Brem ] / Cancer Res.
44 /
[ H.H.Engelhard ] / Surg. Neurol.   DOI   ScienceOn
45 /
[ G.Khang;H.S.Choi;J.M.Rhee;S.C.Yoon;J.C.Cho;H.B.Lee ] / Korea Polymer J.
46 /
[ P.L.Komblith;M.Walker ] / J. Neurosurg.
47 Cell-synthetic Surface Interaction: Physicochemical Surface Modification, Section II. Methods for Cell Delivery Vehicles /
[ G.Khang;H.B.Lee;A.Atala(ed.)R.Lanza(ed.) ] / Methods of Tissue Engineering
48 /
[ P.Skehan;R.Sterng;D.Scudiero;A.Monks;J.McMahon;D.Vistica;J.T.Warren;H.Bikesch;S.Denney;M.R.Boyd ] / J.Natl.Cancer Inst.   DOI
49 /
[ P.L.Kornblith;M.Walke ] / J. Neurosurg.