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Extracts from Rhizopus oryzae KSD-815 of Korean Traditional Nuruk Confer the Potential to Inhibit Hypertension, Platelet Aggregation, and Cancer Metastasis in vitro  

Lee, Sang-Jin (Department of Genetic Engineering, Sungkyunkwan University)
Bae, Hyun-Jin (Department of Genetic Engineering, Sungkyunkwan University)
Ryu, Ji-Yeon (Department of Genetic Engineering, Sungkyunkwan University)
Lee, Dae-Young (Natural Products Chemistry Laboratory, Department of Biotechnology, Kyung Hee University)
Kim, Gye-Won (Research Laboratories, Kooksoondang Brewery Co., Ltd.)
Baek, Na-Min (Natural Products Chemistry Laboratory, Department of Biotechnology, Kyung Hee University)
Kwon, Moo-Sik (Department of Genetic Engineering, Sungkyunkwan University)
Hong, Sung-Youl (Department of Genetic Engineering, Sungkyunkwan University)
Publication Information
Food Science and Biotechnology / v.18, no.6, 2009 , pp. 1423-1429 More about this Journal
Abstract
Rhizopus oryzae KSD-815 was isolated from nuruk that has been used to make Korean traditional wines. This study was performed to investigate the effect of cultures of R. oryzae KSD-815 on cardiovascular disorders and cancer metastasis. Firstly, these cultures were sequentially fractionationed with n-hexane (TAHe), ethylacetate (TAE), n-butanol (TAB), and $H_2O$ (TAW). The TAE inhibited the activity of angiotensin-converting enzyme (ACE) and TAB suppressed platelet aggregation in vitro. TAE and TAB inhibited cell motility of human breast cancer cells. Furthermore, TAW interrupted the formation of neovasculature and tube-like structure, and down-regulated the expression of angiogenic factors, basic fibroblast growth factor (bFGF), tumor necrosis factor-$\alpha$ (TNF-$\alpha$), and hypoxia-inducible factor-$1{\alpha}$ (HIF-$1{\alpha}$) in breast cancer cells. These results indicated that cultures of R. oryzae KSD-815 display the inhibitory activities on hypertension, platelet aggregation, and metastasis, and suggest that these cultures might be further probed for the purposes as therapeutic agents or dietary supplements.
Keywords
Rhizopus oryzae KSD-815; Korean traditional nuruk; anti-hypertension; platelet aggregation; anti-metastatic activity;
Citations & Related Records
Times Cited By KSCI : 6  (Citation Analysis)
Times Cited By Web Of Science : 3  (Related Records In Web of Science)
Times Cited By SCOPUS : 5
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