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Anti-inflammatory Activities of Chopi (Zanthoxylum piperitum A.P. DC) Essential Oil: Suppression of the Inducible Nitric Oxide Synthase and Cellular Adhesion  

Lee, Je-Hyuk (Plant Resource Research Institute, Duksung Women's University)
Chang, Kyung-Mi (Plant Resource Research Institute, Duksung Women's University)
Kim, Gun-Hee (Plant Resource Research Institute, Duksung Women's University)
Publication Information
Food Science and Biotechnology / v.18, no.6, 2009 , pp. 1371-1378 More about this Journal
Abstract
The aim of this study is to elucidate the anti-inflammatory activities of chopi (Zanthoxylum piperitum A.P. DC.) essential oil. Essential oil (EO) of chopi was extracted by steam distillation method, and its major constituents were limonene and geranyl acetate. Chopi-EO decreased approximately 38% of nitrite production, as compared to the lipopolysaccharde (LPS)-induced nitrite production. However, chopi-EO and its components did not quench nitric oxide (NO) chemically in cellfree system, and markedly inhibited approximately 40.4% of inducible nitric oxide synthase (iNOS) mRNA transcription. In addition, the inhibition of E-selectin gene transcription by chopi-EO caused the suppression of cellular adhesion. These results suggest that chopi-EO may exert potential anti-immunological inflammatory activity.
Keywords
chopi; Zanthoxylum piperitum A.P. DC; essential oil; inflammation; interleukin; E-selectin;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
Times Cited By Web Of Science : 1  (Related Records In Web of Science)
Times Cited By SCOPUS : 4
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