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Perilla Leaf Extract Inhibits 3T3-L1 Preadipocytes Differentiation  

Kim, Mi-Ja (Department of Food and Nutrition, Dongduk Women's University)
Kim, Hye-Kyung (Department of Food and Biotechnology, Hanseo University)
Publication Information
Food Science and Biotechnology / v.18, no.4, 2009 , pp. 928-931 More about this Journal
Abstract
Effects of perilla leaf extracts (PLE) on adipocytes differentiation of 3T3-L1 cells were examined. Ethanol extract of PLE treatment significantly decreased lipid accumulation, a marker of adipogenesis, in a dose-dependent manner. Moreover, gene expression levels of peroxisome proliferator-activated receptor ${\gamma}$ ($PPAR{\gamma}$), the key adipogenic transcription factor, were markedly decreased by PLE. PLE also suppressed adipocyte fatty acid binding protein (aP2) and glycerol-3-phosphate dehydrogenase (GPDH), which are adipogenic marker proteins. These results suggest that PLE treatment suppressed differentiation of 3T3-L1 adipocytes, in part by down-regulating expression of adipogenic transcription factor and other specific target genes.
Keywords
perilla leaf; 3T3-L1 cell; peroxisome proliferator-activated receptor ${\gamma}$ ($PPAR{\gamma}$); adipocyte fatty acid binding protein (aP2); glycerol-3-phosphate dehydrogenase (GPDH);
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