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Anti-inflammatory Mechanism of Seaweeds in Murine Macrophage  

Pan, Cheol-Ho (Natural Products Research Center, Korea Institute of Science and Technology Gangneung Branch)
Kim, Eun-Sun (Department of Science Education (Biology), College of Education, Chungbuk National University)
Um, Byung-Hun (Natural Products Research Center, Korea Institute of Science and Technology Gangneung Branch)
Lee, Jae-Kwon (Department of Science Education (Biology), College of Education, Chungbuk National University)
Publication Information
Food Science and Biotechnology / v.18, no.3, 2009 , pp. 813-817 More about this Journal
Abstract
The effect of 4 seaweed extracts (Desmarestia viridis, Dictyopteris divaricata, Scytosiphon lomentaria, and Ishige okamurae) on pro-inflammatory mediators as well as nuclear factor $(NF)-{\kappa}B$ in the stimulated Raw 264.7 cells was investigated. They reduced iNOS and interlukin $(IL)-1{\beta}$ expressions at transcription level. Of those, 3 extracts (D. divaricata, I. okamurae, and S. lomentaria) inhibited the COX-2 expression at translation level. $I{\kappa}B-{\alpha}$ degradation was inhibited by D. divaricata and S. lomentaria extracts. Therefore, we concluded that the extracts from D. divaricata and S. lomentaria could inhibit the activation of murine macrophage through the blocking of $NF-{\kappa}B$ activation.
Keywords
Desmarestia viridis; Dictyopteris divaricata; Scytosiphon lomentaria; Ishige okamurae; inducible nitric oxide synthase (iNOS); $interlukin-1{\beta}$; cyclooxygenase (COX)-2; $I{\kappa}B$; proinflammatory cytokine; anti-inflammation;
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