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Effect of Amination on the Biological Activity of $\beta$-Glucan from Sangwhang (Phellinus linteus)  

Bae, In-Young (Department of Food and Nutrition, Hanyang University)
Shin, Ji-Yoon (Department of Food and Nutrition, Hanyang University)
Lee, Hyeon-Gyu (Department of Food and Nutrition, Hanyang University)
Publication Information
Food Science and Biotechnology / v.17, no.3, 2008 , pp. 683-686 More about this Journal
Abstract
$\beta$-Glucans, which were isolated from sangwhang (Phellinus linteus), were subjected to reductive amination and the biological properties of the derivative were investigated. The degree of substitution of the aminated sangwhang $\beta$-glucan was calculated by elemental analysis to be 1.13. Bronchoalveolar lavage (BAL) experiments showed that the aminated derivative increased nitric oxide production. In addition, the amination enhanced in vitro cytotoxic activities against HT1080 and SNU-C2A cell lines. Thus, the aminated derivative is shown to enhance immune systems by the incorporation of amino groups into the polymer structure.
Keywords
sangwhang$\beta$-glucan; amination; nitric oxide; cytotoxic activity;
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