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Antigenotoxic Effect of Paecilomyces tenuipes Cultivated on Soybeans in a Rat Model of 1,2-Dimethylhydrazine-induced Colon Carcinogenesis  

Park, Eun-Ju (Department of Food and Nutrition, Kyungnam University)
Jeon, Gyeong-Im (Department of Food and Nutrition, Kyungnam University)
Park, Nam-Sook (Department of Life Science and Environmental Biochemistry, College of Natural Resources and Life Science, Pusan National University/Joint Research Center of PNU-Fraunhofer IGB)
Jin, Byung-Rae (College of Natural Resources and Life Science, Dong-A University)
Lee, Sang-Mong (Department of Life Science and Environmental Biochemistry, College of Natural Resources and Life Science, Pusan National University/Joint Research Center of PNU-Fraunhofer IGB)
Publication Information
Food Science and Biotechnology / v.16, no.6, 2007 , pp. 1064-1068 More about this Journal
Abstract
We evaluated the effect of soybean dongchunghacho [SD, cultivated dongchunghacho fungus (Paecilomyces tenuipes) on soybeans] on dimethylhydrazine (DMH)-induced DNA damage and oxidative stress in male F344 rats. The animals were divided into 3 groups and fed a casein-based high-fat, low fiber diet without (DMH group) or with 13%(w/w) of soybean (DMH+S group), or SD (DMH+SD group). One week after beginning the diets, rats were treated weekly with DMH (30 mg/kg, s.c.) for 6 weeks; dietary treatments were continued for the entire experiment and endpoints measured at 9 weeks after the first DMH injection. SD supplementation reduced DMH-induced DNA damage in colon cells and reduced plasma lipid peroxidation. Thus, SD may have therapeutic potential for early-stage colon carcinogenesis.
Keywords
Paecilomyces tenuipes cultivated on soybean; 1,2-dimethylhydrazine (DMH); colon carcinogenesis; DNA damage; antioxidant system;
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Times Cited By KSCI : 5  (Citation Analysis)
Times Cited By Web Of Science : 2  (Related Records In Web of Science)
Times Cited By SCOPUS : 2
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