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Antioxidant and Anti-inflammatory Activities of Allium victorialis subsp. platyphyllum Extracts  

Lee, Je-Hyuk (Plant Resources Research Institute, Duksung Women's University)
Choi, Soo-Im (Plant Resources Research Institute, Duksung Women's University)
Lee, Yong-Soo (Plant Resources Research Institute, Duksung Women's University)
Kim, Gun-Hee (Plant Resources Research Institute, Duksung Women's University)
Publication Information
Food Science and Biotechnology / v.16, no.5, 2007 , pp. 796-801 More about this Journal
Abstract
This study was conducted to investigate antioxidant activity and anti-immunological inflammatory effect of Allium victorialis subsp. platyphyllum extracts (AVPEs). Antioxidant activities of AVPEs were determined by free radical scavenging assay and reducing power test. Leaf-part extract had comparatively better antioxidant activity than other-part extracts. Antioxidant activity of extracts had protective effect for human umbilical vein endothelial cells (HUVECs) against superoxide anions secreted from activated neutrophils. Also, we observed AVPEs had inhibitory effects on the adherence of monocytic THP-1 to HUVEC monolayer to the basal level. Inhibitory effect on cell adhesion was caused by suppression of tumor necrosis factor-${\alpha}\;(TNF-{\alpha})-upregulated$ expression of vascular cellular adhesion molecule-1 (VCAM-1) and E-selectin in HUVECs. From these results, we expect to support the evidence of anti-immunological inflammatory effects of Allium victorialis subsp. platyphyllum (AVP) as a Korean traditional pharmaceutical.
Keywords
Allium victorialis subsp. platyphyllum; antioxidant; anti-inflammation; HUVEC; neutrophils; monocyte;
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Times Cited By KSCI : 4  (Citation Analysis)
Times Cited By Web Of Science : 3  (Related Records In Web of Science)
Times Cited By SCOPUS : 3
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1 Shirataki Y, Motohashi N, Tani S, Sunaga K, Sakagami H, Satoh K, Nakashima H, Kanamoto T, Wolfard K, Molnar J. Antioxidative activity of Allium victorialis L. extracts. Anticancer Res. 21: 3331- 3339 (2001)
2 Park S-H, Park JHY, Kang JS, Kang YH. Involvement of transcription factors in plasma HDL protection against TNF-$\alpha$-induced vascular cell adhesion molecule-1 expression. Int. J. Biochem. Cell B. 35: 168-182 (2003)   DOI   ScienceOn
3 Duh PD. Antioxidant activity of burdock (Arctium lappa Linne): Its scavenging effect on free radical and active oxygen. J. Am. Oil. Chem. Soc. 75: 455-461 (1998)   DOI   ScienceOn
4 Broide DH, Lotz M, Cuomo AJ, Coburn DA, Federman EC, Wasserman SI. Cytokines in symptomatic asthma airway. J. Allergy Clin. Immunol. 89: 958-967 (1992)   DOI
5 Silverman MD, Zamora DO, Pan Y, Texeira PV, Planck SR, Rosenbaum JT. Cell adhesion molecule expression in cultured human iris endothelial cells. Invest. Ophthalmol. Vis. Sci. 42: 2861- 2866 (2001)
6 Choi EM. Suppressive effects of potato (Salanum tuberlosum) on type II collagen-induced arthritis in DBA/1J mice. Food Sci. Biotechnol. 16: 43-48 (2007)   과학기술학회마을
7 Song HS, Moon KY. In vitro antioxidant activity profiles of $\beta$- glucans isolated from yeast Saccharomyces cerevisiae and mutant Saccharomyces cerevisiae IS2. Food Sci. Biotechnol. 15: 437-440 (2006)   과학기술학회마을
8 Lee EJ, Kim KS, Jung HY, Kim DH, Jang HD. Antioxidant activities of garlic (Allium sativum L.) with growing districts. Food Sci. Biotechnol. 14: 123-130 (2005)
9 Nishimura H, Takahashi T, Wijaya CH, Satoh A, Ariga T. Thermo-chemical transformation of sulfur compounds in Japanese domestic Allium, Allium victoialis L. Biofactors 13: 257-263 (2000)   DOI
10 Oyaizu M. Studies on product of browning reaction : Antioxidative activities of products of browning reaction prepared from glucosamine. Jpn. J. Nutr. 44: 307-315 (1986)   DOI
11 Padayatty SJ, Levine M. New insights into the physiology and pharmacology of vitamin C. Can. Med. Assoc. J. 164: 353-355 (2001)
12 Amrani Y, Chen H, Panettieri R. Activation of tumor necrosis factor receptor 1 in airway smooth muscle: A potential pathway that modulates bronchial hyper-responsiveness in asthma? Respir. Res. 1: 49-53 (2000)   DOI   ScienceOn
13 Rossi LW, Horn NA, Buhre W, Gass F, Hutschenreuter G, Rossaint R. The effect of isoflurane on neutrophil selectin and ${\beta}_2$-integrin activation in vitro. Anesth. Analg. 95: 583-587 (2002)   DOI
14 Maksimowicz-McKinnon K, Bhatt DL, Calabrese LH. Recent advances in vascular inflammation: C-reactive protein and other inflammatory biomarkers. Curr. Opin. Rheumatol. 16: 18-24 (2004)   DOI   ScienceOn
15 Wang Y, Russo TA, Kwon O, Chanock S, Rumsey SC, Levine M. Ascorbate recycling in human neutrophils: Induction by bacteria. P. Natl. Acad. Sci. USA 94: 13816-13819 (1997)
16 Choi JS, Choi YJ, Park SH, Kang JS, Kang YH. Flavones migrate tumor necrosis factor-$\alpha$-induced adhesion molecule upregulation in cultured human endothelial cells: Role of nuclear factor-$\kappa$B. J. Nutr. 134: 1013-1019 (2004)
17 Koskinen PK, Lemstrom KB. Adhesion molecule P-selectin and vascular cell adhesion molecule–1 in enhanced heart allograft arteriosclerosis in the rat. Circulation 95: 191-196 (1997)   DOI   ScienceOn
18 Moon KS. Usage and components of herbal medicine. Scientific Encyclopedia Co., Pyongyang, Korea. pp. 671-672 (1984)
19 Hampton MB, Kettle AJ, Winterbourn CC. Inside the neutrophil phagosome: Oxidants, myeloperoxidase, and bacterial killing. Blood 92: 3007-3017 (1998)
20 Lee CW, Lin WN, Lin CC, Luo SF, Wang JS, Pouyssegur J, Yang CM. Transcriptional regulation of VCAM-1 expression by tumor necrosis factor-$\alpha$ in human tracheal smooth muscle cells: Involvement of MAPKs, NF-$\kappa$B, p300, and histone acetylation. J. Cell. Physiol. 207: 174-186 (2006)   DOI   ScienceOn
21 Wijaya CH, Muchyani D, Lalel HJ, Zakaria F, Kowara S. Antiplatelet aggregation potencies of some Alliums pp. grown in Indonesia. Nat. Prod. Sci. 2: 37-42 (1996)
22 Liakopoulou-Kyriakidids M, Sinakos Z, Kyriakidids DA. Identification of Alliin, a constituent of Allium cepa with an inhibitory effect on platelet aggregation. Phytochemistry 24: 600-610 (1985)   DOI   ScienceOn
23 Corpe CP, Lee JH, Kwon O, Eck P, Narayanan J, Kirk KL, Levine M. 6-Bromo-6-deoxy-L-ascorbic acid : An ascorbate analog specific for $Na^+$-dependent vitamin C transporter but not glucose transporter pathways. J. Biol. Chem. 280: 5211-5220 (2005)   DOI   ScienceOn
24 Lee KT, Choi JH, Kim DH, Son KH, Kim WB, Kwon SH, Park HJ. Constituents and the antitumor principle of Allium victorialis var. platyphyllum. Arch. Pharm. Res. 24: 44-50 (2001)   DOI   ScienceOn
25 Amarowicz R, Troszyñska A, Shahidi F. Antioxidant activity of almond seed extract and its fractions. J. Food Lipids 12: 344-358 (2005)   DOI   ScienceOn
26 Nuutila AM, Puupponen-Pimia R, Aarni M, Oksman-Caldentey KM. Comparison of antioxidant activities of onion and garlic extracts by inhibition of lipid peroxidation and radical scavenging activity. Food Chem. 81: 485-493 (2003)   DOI   ScienceOn
27 Guo J, Wang MH. Antioxidant and antidiabetic activities of Ulmus davidiana extracts. Food Sci. Biotechnol. 16: 55-61 (2007)   과학기술학회마을
28 Gordon MH. The mechanism of antioxidant action in vitro. pp. 1- 18. In: Food Antooxidants. Hudson BJF (ed). Elsevier, London, UK (1990)
29 Richards RS, Roberts TK, Dunstan RH, McGregor NR, Butt HL. Erythrocyte antioxidant systems protect cultured endothelial cells against oxidant damage. Biochem. Mol. Biol. Int. 46: 857-865 (1998)
30 Tsukimori K, Fukushima K, Tsushima A, Nakano H. Generation of reactive oxygen species by neutrophils and endothelial cell injury in normal and preeclamptic pregnancies. Hypertension 46: 696-700 (2005)   DOI   ScienceOn
31 Ludwig A, Lorenz M, Grimbo N, Steinle F, Meiners S, Bartsch C, Stangl K, Baumann G, Stangl V. The tea flavonoid epigallocatechin- 3-gallate reduces cytokine-induced VCAM-1 expression and monocyte adhesion to endothelia cells. Biochem. Biophys. Res. Co. 316: 659-665 (2004)   DOI   ScienceOn