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Effect of Colored Potato Flakes Against Acetaminophen-induced Liver Damage in Rats  

Ohba, Kiyoshi (Hokkaido Tokachi Area Regional Food Processing Technology Center)
Watanabe, Shoko (Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine)
Han, Kyu-Ho (Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine)
Hashimoto, Naoto (Department of Upland Agriculture, National Agricultural Research Center for Hokkaido Region)
Noda, Takahiro (Department of Upland Agriculture, National Agricultural Research Center for Hokkaido Region)
Shimada, Ken-Ichiro (Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine)
Tanaka, Hisashi (Somatech Center, House Foods Corporation)
Sekikawa, Mitsuo (Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine)
Fukushima, Michihiro (Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine)
Publication Information
Food Science and Biotechnology / v.16, no.3, 2007 , pp. 463-469 More about this Journal
Abstract
We examined the hepatoprotective effects of colored potato flakes on acetaminophen (AAP)-induced liver damage in rats. F344/DuCrj (8 week-old) rats were fed a cholesterol-free diet with 54.9486 g of ${\alpha}$-corn starch/100g diet and were orally treated with 25% colored flakes of Kitamurasaki (KM: light purple), Northern Ruby (NR: red), and Shadow Queen (SQ: medium purple) potatoes co-administered with AAP (0.5 g/100 g diet) for 4 weeks. The hepatic thiobarbituric acid-reactive substances (TBARS) values in the KM, NR, and SQ groups were significantly lower (p<0.05) than those in the control groups with and without AAP. Furthermore, the hepatic catalase, Mn-superoxide dismutase (SOD), and Cu/Zn-SOD mRNA levels in the KM, NR, and SQ groups were higher than those in the control groups with and without AAP. The present findings suggest that colored potato flakes are useful as a prophylactic agent against oxidative liver damage.
Keywords
acetaminophen; catalase; color potato flake; Cu/Zn-superoxide dismutase; Mn-superoxide dismutase; TBARS value;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
Times Cited By Web Of Science : 3  (Related Records In Web of Science)
Times Cited By SCOPUS : 2
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