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Mevinolin Production by Monascus pilosus IFO 480 in Solid State Fermentation of Soymeal  

Pyo, Young-Hee (Traditional Food Research Division, Korea Food Research Institute)
Lee, Young-Chul (Traditional Food Research Division, Korea Food Research Institute)
Publication Information
Food Science and Biotechnology / v.15, no.4, 2006 , pp. 647-649 More about this Journal
Abstract
Mevinolin, a fungal metabolite, is a potent inhibitor of 3-hydroxy-methyl-3-glutaryl-coenzyme A (HMG-CoA) reductase, the rate-controlling enzyme in cholesterol biosynthesis. In this investigation, the optimum factors for mevinolin production by Monascus pilosus IFO 480 in soymeal fermentation were studied. The highest yield of mevinolin, 2.82 mg mevinolin per g dry weight, without citrinin (a toxic fungal secondary metabolite) was obtained after 21 days of fermentation at $30^{\circ}C$ at 65% moisture content, particle size 0.6-0.9 mm, and initial substrate pH of 6.0. Mevinolin was present in the fermentation substrate predominantly in the hydroxycarboxylate form (open lactone, 92.1-97.3%), which is currently being used as a hypocholesterolemic agent.
Keywords
Monascus pilosus; mevinolin; citrinin; hypocholesterolemic agent; soymeal fermentation;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
Times Cited By Web Of Science : 6  (Related Records In Web of Science)
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