Browse > Article

Effects of Ethanol Extract of Ligularia fischeri Leaves on Freund's Complete Adjuvant-Induced Model of Chronic Arthritis in Mice  

Choi, Eun-Mi (Department of Food & Nutrition, Kyung Hee University)
Publication Information
Food Science and Biotechnology / v.15, no.2, 2006 , pp. 277-282 More about this Journal
Abstract
The aim of this study was to investigate the anti-inflammatory and anti-oxidant activity of Ligularia fischeri leaf extract on adjuvant induced arthritis in experimental mice. The oral administration of the L. fischeri leaf extract (LF), at doses of 100 and 200 mg/kg body weight once a day for 3 weeks, significantly reduced hindpaw swelling and the production of inflammatory cytokines (tumor necrosis factor(TNF)-${\alpha}$, interleukin(IL)-$1{\beta}$, and IL-6). Treatment with LF (100 mg/kg) also decreased the serum levels of triglyceride and low density lipoprotein(LDL)-cholesterol, and increased high density lipoprotein(HDL)-cholesterol contents compared with those of a control group. The induction of arthritis significantly increased oxidized proteins such as protein carbonyl, advanced oxidation protein products, and advanced glycation end-products in the lung, heart, and brain. Treatment with LF for 3 weeks reduced the levels of oxidized proteins. These results suggest that L. fischeri extract might be beneficial in the treatment of chronic inflammatory disorders.
Keywords
Ligularia fischeri; inflammation; Freund's complete adjuvant;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 2  (Related Records In Web of Science)
연도 인용수 순위
1 Silvan AM, Abad MJ, Bermejo P, Villar AM. Adjuvant-carrageenaninduced inflammation in mice. Gen. Pharmacol. 29: 665-669 (1997)   DOI   ScienceOn
2 Choi OJ. Usage and constituents of medicinal plants. Seoul, Korea. Iweolseogak, p. 621 (1991)
3 Choi J, Park JK, Lee KT, Park KK, Kim WB, Lee JH, Jung HJ, Park HJ. In vivo antihepatotoxic effects of Ligularia fischeri var. spiciformis and the identification of the active component, 3,4dicaffeoylquinic acid. J. Med. Food 8: 348-352 (2005)   DOI   ScienceOn
4 Sironi M, Gadina M, Kankova M, Riganti F, Mantovani A, Zandalasini M, Ghezzi P. Differential sensitivity of in vivo TNF and IL-6 production to modulation by anti-inflammatory drugs in mice. Int. J. Immunopharmacol. 14: 1045-1050 (1992)   DOI   ScienceOn
5 Lampert MB,Weiss SJ. The chlorinating potential of the human monocyte. Blood 62: 645-651 (1983)
6 Isomaki P, Punnonen J. Pro- and anti-inflammatory cytokines in rheumatoid arthritis. Ann. Med. 29: 499-550 (1997)   DOI   ScienceOn
7 Corsi MM, Fulgenzi A, Tiengo M, Pravettoni G, Gaja G, Ferrero ME. Effect of somatostatin on $\beta$-endorphin release in rat experimental chronic inflammation. Life Sci. 64: 2247-2254 (1999)   DOI   ScienceOn
8 Theze J. The cytokine networks and immune functions. Oxford University Press. Oxford, UK p. 373 (1999)
9 Singh, R., Barden, A., Mori, T., Beilin, L., Advanced glycation endproducts: a review. Diabetologia 44: 129-146 (2001)   DOI
10 Kopp E, Ghosh S. Inhibition of NF-kappa B by sodium salicylate and aspirin. Science 265: 956-959 (1994)   DOI   ScienceOn
11 Miyata M, lida Y, Horie K, Cai Z, Sugiyama S, Maeda K. Pathophysiology of advanced glycation end-products in renal failure. Nephrol. Dial. Transpl. 11: 27-80 (1996)   DOI   ScienceOn
12 Tietz NW (ed.). Textbook of clinical chemistry. WB Com. PA, USA (1986)
13 Srinivasan K, Muruganandan S, Lal J, Chandea S, Tandan SK, Prakash VR. Evaluation of anti-inflammatory activity of Pongamia pinnata leaves in rats. J. Ethnopharmacol. 78: 151-157 (2001)   DOI   ScienceOn
14 Kim AJ, Yuh JS, Kim SY, Park SJ, Sung CJ. Anti-inflammatory Effect of the Ostrich Extract Combined with Korean Herbal Medicine. Food Sci. Biotechnol. 13: 472-475 (2004)
15 Elenkov IJ, Chrousos GP. Stress, cytokine patterns and susceptibility to disease. Bailliere's best practice & research. Clin. Endocrinol. Metab. 13: 583-595 (1999)
16 Witko-Sarsat V, Friedlander M, Khoa NT, Blandin C, Nguyen AT, Canteloup S. Advanced oxidation protein products as novel mediators of inflammation and monocyte activation in chronic renal failure. Immunology 161: 2524-2532 (1998)
17 Takagi M, Kasayama S, Yamamoto T. Advanced glycation end products stimulate interleukin 6 production by human bone derived cells. J. Bone Miner. Res. 12: 439-46 (1997)   DOI   ScienceOn
18 Witko V, Nguyen AT, Descamps-Latscha B. Microtiter plate assay for phagocyte-derived taurine-chloramines. J. Clin. Lab. Anal. 6: 4753 (1992)   DOI
19 Klimov AN, Popov AV, Nagomev VA. Effect of high density lipoproteins on permeability of rabbit aorta to low density lipoproteins. Atherosclerosis 55: 217-223 (1985)   DOI
20 Gauldie SD, McQueen DS, Clarke CJ, Chessell IP. A robust model of adjuvant-induced chronic unilateral arthritis in two mouse strains. J. Neurosci. Meth. 139: 281-291(2004)   DOI   ScienceOn
21 Fagan JM, Sleczka BG, Sohar J. Quantification of oxidative damage to tissue proteins. Int. J. Biochemi. Cell BioI. 31: 751-757 (1999)   DOI   ScienceOn
22 Hong H, Johnson P. Antioxidant enzyme activities and lipid peroxidation levels in exercised and hypertensive rat tissues. Int J Biochem. Cell BioI. 27: 923-931 (1995)   DOI   ScienceOn
23 Dalle-Donne I, Rossi R, Giustarini D, Milzani A, Colombo R. Protein carbonyl groups as biomarkers of oxidative stress. Clin. Chim. Acta 329: 23-38 (2003)   DOI   ScienceOn
24 Hang L, Theofilopoulus AN, Dixon FJ. A spontaneous rheumatoid arthritis-like disease in MRL/l mice. J. Exp. Med. 155: 1690-1692 (1982)   DOI
25 Choi EM, Lee KH, Koo SJ. Effects of Ethanol Extract of Potato (Solanum tuberiosum) on Freund's Complete Adjuvant-induced Model of Chronic Arthritis in Mice. Food Sci. Biotechnol. 14: 228232 (2005)
26 Kalousava M, Zima T, Tesar V, Lachmanova J. Advanced glycation end products and advanced oxidation protein products in hemodialyzed patients. Blood Purifieat. 20: 531-536 (2002)   DOI   ScienceOn
27 Cannon JG.Inflammatory cytokines in nonpathological states. News Physiol. Sci. 15: 298-303 (2000)
28 Maziere C, Auclair M, Maziere JC. Tumor necrosis factor enhances low density lipoprotein oxidative modification by monocytes and endothelial cells. FEBS Lett. 338: 43-46 (1994)   DOI   ScienceOn
29 Lee KT, Koo SJ, Jung SH, Choi J, Jung HJ, Park HJ. Structure of three new terpenoids, spiciformisins a and b, and monocyclosqualene, isolated from the herbs of Ligularia fischeri var. spiciformis and cytotoxicity. Arch. Pharm. Res. 25: 820-823 (2002)   DOI   ScienceOn
30 Park HJ, Kwon SH, Yoo KO, Sohn lC, Lee KT. Sesquiterpenes from the leaves of Ligularia jischeri var. spiciformis. Planta Med. 66: 783-784 (2000)   DOI   ScienceOn
31 Gupta M, Mazumdar UK, Sivakumar T, Vamsi ML, Karki SS, Sambathkumar R, Manikandan L. Evaluation of anti-inflammatory activity of chloroform extract of Bryonia laciniosa in experimental animal models. BioI. Pharm. Bull. 26: 1342-B44 (2003)   DOI   ScienceOn
32 Johnson GD. Correlation of color and constitution. 1. 2,4-dinitrophenylhydrozones. J. Am. Chem. Soc. 75: 2720-2723 (1953)   DOI
33 Cockerill GW, Rye K, Gamble JR. High-density lipoproteins inhibit cytokine-induced expression of endothelial cell adhesion molecules. Arterioscl. Throm. Vas. 15: 1987-1994 (1995)   DOI   ScienceOn
34 Navab M, Imes SS, Hough GP. Monocyte transmigration induced by modification of LDL in cocultures of human aortic wall cells is due to induction of MCP 1 synthesis and is abolished by HDL. J. Clin. Invest 88: 2039-2046 (1991)   DOI
35 Jimenez I, Lissi E, Speisky H: Free radical-induced inactivation of lysozyme and carbonyl residue generation in protein are not necessarily associated. Arch. Biochem. Biophys. 381: 247-52 (2000)   DOI   ScienceOn
36 Jeong SH, Koo SJ, Choi JH, Park JH, Ha JH, Park HJ, Lee KT. Intermedeol isolated from the leaves of Ligularia jischeri var. spiciformis induces the differentiation of human acute promyeocytic leukemiaHL-60 cells. Planta Med. 68: 881-885 (2002)   DOI   ScienceOn
37 Chajek-Shaul T, Friedman G, Stein O. Mechanism of the hypertriglyceridemia induced by tumor necrosis factor administration to rats. Biochim. Biophys. Acta 1001: 316--324 (1989)   DOI   ScienceOn