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Effects of Intraperitoneal Administration of Lactococcus lactis ssp. lactis Cellular Fraction on Immune Response  

Kim, Ji-Yeon (Department of Food Standard Evaluation, Korea Food & Drug Administration)
Lee, Seong-Kyu (Department of Applied Biological Chemistry, The University of Tokyo)
Jeong, Do-Won (School of Agricultural Biotechnology, and Center of Agricultural Biomaterials, Seoul National University)
Hachimura, Satoshi (Department of Applied Biological Chemistry, The University of Tokyo)
Kaminogawa, Shuichi (Department of Food Science and Technology, College of Bioresource Science, Nihon University)
Lee, Hyong-Joo (School of Agricultural Biotechnology, and Center of Agricultural Biomaterials, Seoul National University)
Publication Information
Food Science and Biotechnology / v.14, no.3, 2005 , pp. 405-409 More about this Journal
Abstract
Cellular components of Lactococcus lactis ssp. lactis (heat-killed whole cells, cytoplasm, and cell walls) were tested for their in vivo immunopotentiating activities. Peritoneal macrophages from mice injected intraperitoneally with cell-wall fractions exhibited significantly greater phagocytic activity than groups injected with whole cells or cytoplasm fraction. Cytotoxicity of natural-killer cells was highest in cytoplasm fractions. Production of cytokines (IFN-${\gamma}$, IL-2, IL-6, and IL-12) in spleen cells was significantly higher when cellular components were injected intraperitoneally, and tended to be higher in whole-cell and cytoplasm groups than in cell-wall group. These results demonstrate lactic acid bacteria whole cells and their cytoplasm and cell-wall tractions have immunopotentiating activities.
Keywords
Cytokine; Lactococcus lactis ssp. lactis; NK cell activity; Phagocytic activity; Immunopotentiating activity;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
Times Cited By Web Of Science : 4  (Related Records In Web of Science)
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