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SEM Observation for the Damage of Inner Hair Cell Stereocilia of Guinea Pig Cochlea after Loud Tone Exposure  

Jarng Soon Suck (Dept. of Information, Control & Instrumentation, Chosun University)
Abstract
The inner hair cell stereocilia of the guinea pig cochlea was examined under a scanning electron microscope (SEM) after loud tone exposure onto the ear drum of the animal. Before and after guinea pigs were exposed to intensive and continuous tone such as 106 dB SPL in intensity, the functioning of the cochlea was monitored by N1-N2 audiograms. The structural damage of the stereocilia of inner hair cells (IHCs) and outer hair cells (OHCs) was examined using the SEM in x 1500 magnification. The comparison between the functional change of the cochlea and the structural damage of the IHC stereocilia is done by means of photographic observation. It can be shown that the functional change might be related to the structural damage of the IHC stereocilia after intensive acoustic trauma.
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1 M. C. Brown, D. I. Smith, A. L. Nuttall 'Anethesia and surgical traumatheir influence on the guniea pig compound action potential', Hearing Research, 10, 345-358, 1983   DOI   ScienceOn
2 D. T. Kemp 'Stimulated acoustic emissions from within the human auditory system', J. Neurophysiol., 34, 802-816, 1978
3 D. O. Kim 'Active and nonlinear cochlear biomechanics and the role of outer-hair-cell subsystem in the mammalian auditory system', Hearing Res., 22, 105-114, 1986   DOI   PUBMED   ScienceOn
4 D. Robertson, B. M. Johnstone 'Acoustic trauma in the guinea pig cochleaearly changes in ultrastructure and neural threshold', Hearing Res., 3, 167-179, 1980   DOI   ScienceOn
5 D. Robertson 'Effects of acoustic trauma on stereocilia structure and spiral ganglion cell tunning properties in the guinea pig cochlea', Hearing Res., 7, 55-74, 1982   DOI   PUBMED   ScienceOn
6 P. Dallos, M. A. Cheatham 'Compound action potential (AP) tunning curves', J. Acoust. Soc. Am., 59 (3), 591-597, 1976   DOI   ScienceOn
7 J. O. Pickles, M. P. Osborne, S. D. Comis 'Vulnerability of tip links between stereocilia to acoustic trauma in the guniea pig', Hearing Research, 25, 173-183, 1987   DOI   PUBMED   ScienceOn
8 J. F. Ashmore 'A fast rnotile response in guinea pig outer hair cellsthe cellular basis of the cochlear amplifier', J. Physiol., 388, 323-347, 1987   DOI
9 M. C. Liberman, L. W. Dodds 'Chronic ultrastructural changes in acoustic traumaSerial-section reconstruction of stereocilia and cuticular plates', Hearing Res., 26, 65-88, 1987   DOI   PUBMED   ScienceOn
10 I. M. Hunter-Duvar, Morphology of the normal and the acoustically damaged cochlea, In Scanning Electron Microscopy, II, (ITT Research Institute, Chicago, 1977)
11 D. T. Kemp, Cochlear echoes - implications for noise induced hearing loss InNew perspectives in noise-induced hearing loss, Editors. R. P. Hamernik, D. Henderson, R. Salvi, (Raven Press, New York, 1982), pp.189-207
12 J. O. Pickles 'Recent advances in cochlear physiology', Progress in Neurobiology, 24, 1-42, 1985   DOI   PUBMED   ScienceOn
13 D. Robertson 'Combined electrophysiology and ultrastructure of acoustic trauma in the guinea pig cochlea', Arch. Otorhinolaryngol., 230, 257-263, 1981   DOI   PUBMED   ScienceOn
14 M. C. Liberman 'Single-neuron labeling and chronic cochlear pathology. I. Threshold shift and characteristic-frequency shift', Hearing Res., 16, 33-41, 1984   DOI   PUBMED   ScienceOn
15 A. J. Derbyshire, H. Davis 'The action potential of the auditory nerve', Am. J. Physiol., 113, 476-504, 1935
16 E. de. Boer 'The inverse problem solved for a three-dimensional model of the cochlea. I. Analysis', J. Acoust. Soc. Am., 98 (2), 896-903, 1995   DOI   PUBMED   ScienceOn
17 P. Nilson, B. Erlandson, H. Hakanson, A. Ivarsson, J. Wersall, Anatomical changes in the cochlea of the guinea pig following industrial noise exposure. New perspectives on noise-induced hearing loss, Edited by R. P. Hamernik, D. Handerson, R. Salvi, (Raven Press, New York, 1982), pp.69-86
18 E. de. Boer 'The inverse problem solved for a three-dimensional model of the cochlea. II. Application to experimental data sets', J. Acoust. Soc. Am., 98 (2), 896-903, 1995   DOI   PUBMED   ScienceOn
19 S.S.Jarng 'N1-N2 Audiograms of the Guinea Pig Cochlea', Journal of the Korea Society of Medical and Biological Engineering, 16 (1), 77-83, 1995
20 S.S.Jarng 'Comparison of N1-N2 Audiograms pre- and post- loud tone exposure', Journal of the Korea Society of Medical and Biological Engineering, 16 (4), 471-480, 1995
21 S.S.Jarng, A computer and experimental study of cochlear function, (M.Sc. Thesis at the University of Birmingham, 1988)
22 J.S. Kim, S.H. Hong 'Study on the effect on the compound action potential by guinea pig anesthesia' J. of Korean ENT Soc. 36 (4), 601-611, 1993
23 A. R. Cody, D. Robertson 'Variability of noise-induced damage in the guinea pig cochleaelectrophysiological and morphological correlates after strictly controlled exposure', Hearing Res., 9 (1), 55-70, 1983   DOI   ScienceOn