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http://dx.doi.org/10.1016/j.shaw.2020.01.003

Moist and Mold Exposure is Associated With High Prevalence of Neurological Symptoms and MCS in a Finnish Hospital Workers Cohort  

Hyvonen, Saija (Tyoterveys Meditare)
Lohi, Jouni (Lapland Central Hospital, Department of Pathology)
Tuuminen, Tamara (Medical Center Kruunuhaka Oy)
Publication Information
Safety and Health at Work / v.11, no.2, 2020 , pp. 173-177 More about this Journal
Abstract
Background: Indoor air dampness microbiota (DM) is a big health hazard. Sufficient evidence exists that exposure to DM causes new asthma or exacerbation, dyspnea, infections of upper airways and allergic alveolitis. Less convincing evidence has yet been published for extrapulmonary manifestations of dampness and mold hypersensitivity syndrome). Methods: We investigated the prevalence of extrapulmonary in addition to respiratory symptoms with a questionnaire in a cohort of nurses and midwives (n = 90) exposed to DM in a Helsinki Obstetric Hospital. The corresponding prevalence was compared with an unexposed cohort (n = 45). Particular interest was put on neurological symptoms and multiple chemical sensitivity. Results: The results show that respiratory symptoms were more common among participants of the study vs. control cohort, that is, 80 vs 29%, respectively (risk ratio [RR]: 2.56, p < 0.001). Symptoms of the central or peripheral nervous system were also more common in study vs. control cohort: 81 vs 11% (RR: 6.63, p < 0.001). Fatigue was reported in 77 vs. 24%, (RR: 3.05, p < 0.001) and multiple chemical sensitivity in 40 vs. 9%, (RR: 3.44, p = 0.01), the so-called "brain fog", was prevalent in 62 vs 11% (RR: 4.94, p < 0.001), arrhythmias were reported in 57 vs. 2.4% (RR: 19.75, p < 0.001) and musculoskeletal pain in 51 vs 22% (RR: 2.02, p = 0.02) among participants of the study vs. control cohort, respectively. Conclusion: The results indicate that the exposure to DM is associated with a plethora of extrapulmonary symptoms. Presented data corroborate our recent reports on the health effects of moist and mold exposure in a workplace.
Keywords
Dampness and mold hypersensitivity syndrome; Moisture damaged buildings; Multiple chemical sensitivity; Mycotoxins; Neuroinflammation;
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1 Wang J, Zhao Z, Zhang Y, Li B, Huang C, Zhang X, Zhao Z, Zhang Y, Li B, Huang C, Zhang X, Deng Q, Lu C, Qian H, Yang X, Sun Y, Sundell J, Norback D. Asthma, allergic rhinitis and eczema among parents of preschool children in relation to climate, and dampness and mold in dwellings in China. Environ Int Sep. 2019;130. https://doi.org/10.1016/j.envint.2019.104910.
2 Kuhn D, Ghannoum M. Indoor mold, toxigenic fungi, and Stachybotrys chartarum: infectious disease perspective. Clin Microbiol Rev 2003;16:144-72.   DOI
3 Curtis L, Lieberman A, Stark M, Rea W, Vetter M. Adverse health effects of indoor molds. J Nutr Environ Med 2004;14:261-74.   DOI
4 Campbell A, Thrasher J, Gray M, Voijdani A. Mold and mycotoxins: effects on the neurological and immune systems in humans. Adv Appl Microbiol 2004;55:375-406.   DOI
5 Zhang X, Norback D, Fan Q, Bai X, Li T, Zhang Y., Lu C, Qian H, Xu Y, Sun Y, Sundell J, Wang J. Dampness and mold in homes across China: association with rhinitis, ocular, throat and dermal symptoms, headache and fatigue among adults. Indoor Air 2019;29:30-42.   DOI
6 Ratnaseelan A, Tsilioni I, Theoharides T. Effects of mycotoxins on neuropsychiatric symptoms and immune processes. Clin Ther 2018;40:903-7.   DOI
7 Randolph T. Sensitivity to petroleum including its derivatives and antecedents. J Lab Clin Med 1952;40:931-2.
8 Lacour M, Zunder T, Schmidtke K, Vaith P, Scheidt C. Multiple chemical sensitivity syndrome (MCS)-suggestions for an extension of the U.S. MCS-case definition. Int J Hyg Environ Health 2005;208:141-51.   DOI
9 Cullen M. Multiple chemical sensitivities: summary and directions for future investigators. Occup Med 1987;2:801-4.
10 Bartha L, Baumzweiger W, Buscher D, Callender T, Dahl K, Davidoff A, Donnay A, Edelson S, Elson B, Elliott E, Flayhan D, Heuser D, Keyl P, Kilburn K. Multiple chemical sensitivity: a 1999 consensus. Arch Environ Health 1999;4: 147-9.
11 Dantoft T, Andersson L, Nordin S, Skovbjerg S. Chemical intolerance. Curr Rheumatol Rev 2015;11:167-84.   DOI
12 Tuuminen T, Rinne K. Severe sequelae to mold-related illness as demonstrated in two Finnish cohorts. Front Immunol 2017;3:382.   DOI
13 Tuuminen T, Jaaskelainen T, Vaali K, Polo O. Dampness and mold hypersensitivity syndrome and vaccination as risk factors for chronic fatigue syndrome. Autoimm Rev 2019;8:107-8.   DOI
14 Hyvönen S, Syrjala H. Asthma case cluster during renovation of a waterdamaged and toxic building. Microorganisms 2019 Dec 3;7(12). https://doi.org/10.3390/microorganisms7120642.
15 Bauer T, Sipos W, Stark T, Kaser T, Knecht C, Brunthaler R., Saalmüller A, Hofmann T, Ehling-Schulz M. First insights into within host translocation of the Bacillus cereus toxin cereulide using a porcine model. Front Microb 2018 Nov 7;9:2652. https://doi.org/10.3389/fmicb.2018.02652 eCollection 2018.   DOI
16 Tuuminen T, Antila E. Multiple chemical sensitivity. the disease is tangible - the reactivity is physiological. Lambert Acad Publ. 2018, ISBN 978-613-7-34824-6; 2018.
17 Pall M, Anderson J. The vanilloid receptor as a putative target of diverse chemicals in multiple chemical sensitivity. Arch Environ Health 2004;59:363-75.   DOI
18 Pall M. Multiple chemical sensitivity: toxicological questions and mechanisms. 3rd ed. New Jersey: General and Applied Toxicology; 2009.
19 Meggs W. The role of neurogenic inflammation in chemical sensitivity. Ecopsychology May 2017;9(2). https://doi.org/10.1089/eco.2016.0045.
20 Carruthers B, van de Sande I, DeMeirleir K, Klimas N, Broderick G, Mitchell T., Staines D, Powles C, Speight N, Vallings R, Bateman L, Baumgarten-Austrheim B, Bell B, Carlo-Stella N, Chia J, Darragh A, Jo D, Lewis D, Light A, Marshall-Gradisbi S, Mena I, Mikovits J, Miwa K,Murovska M, Pall M, Stevens S. Myalgic encephalomyelitis: international consensus criteria. J Intern Med 2011;270:327-38.   DOI
21 Somppi T. Non-thyroidal illness syndrome in patients exposed to indoor air dampness microbiota treated successfully with triiodothyronine. Front Immunol 2017 Aug 7;8:919. https://doi.org/10.3389/fimmu.2017.00919eCollection 2017.   DOI
22 Jousilahti P, Haahtela T, Laatikainen T, Makela M, Vartiainen E. Asthma and respiratory allergy prevalence is still increasing among Finnish young adults. Eur Respir J 2016;47:985-7.   DOI
23 Tuuminen T, Lohi J. Immunological and toxicological effects of bad indoor air to cause Dampness and Mold Hypersensitivity Syndrome. AIMS Allergy Immunol 2018;2:190-203.   DOI
24 Valtonen V. Clinical diagnosis of the dampness and mold hypersensitivity syndrome: review of the literature and suggested diagnostic criteria. Front Immunol 2017;8:951.   DOI
25 Tuuminen T, Lohi J. Dampness and mold hypersensitivity syndrome is a Biotoxicosis that should be diagnosed Promptly. Adv Clin Toxicol 2019;4. https://doi.org/10.23880/act-16000144.
26 Tuuminen T, Vaali K, Valtonen V. In: Dampness and mold hypersensitivity syndrome as an umbrella for many chronic diseases -the clinician's point of view. 2nd ed. Encyclopedia in Environmental Health, Elsevier Inc; 2020. 11454 p.
27 Pall M. Nitric oxide synthase partial uncoupling as a key switching mechanism for the NO/ONOO-cycle. Med Hypotheses 2007;69:821-5.   DOI
28 Fisk W, Chan W, Johnson A. Does dampness and mold in schools affect health? Results of a meta-analysis. Indoor Air 2019;29:895-902.   DOI
29 WHO Regional Office for Europe. In: Damp and mould. Health risks, prevent and remedial actions. Copenhagen: WHO; 2009.