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http://dx.doi.org/10.4142/jvs.21247

Prevalence and treatment of gastric ulcers in Thoroughbred racehorses of Korea  

Hwang, Hyeshin (Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Seoul National University)
Dong, Hee-Jin (Department of Veterinary Pathobiology and Preventive Medicine, BK21 PLUS Program for Creative Veterinary Science Research, Research Institute for Veterinary Science and College of Veterinary Medicine, Seoul National University)
Han, Janet (College of Veterinary Medicine, Western University of Health Sciences)
Cho, Seongbeom (Department of Veterinary Pathobiology and Preventive Medicine, BK21 PLUS Program for Creative Veterinary Science Research, Research Institute for Veterinary Science and College of Veterinary Medicine, Seoul National University)
Kim, Yongbaek (Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Seoul National University)
Lee, Inhyung (Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Seoul National University)
Publication Information
Journal of Veterinary Science / v.23, no.2, 2022 , pp. 19.1-19.9 More about this Journal
Abstract
Background: Gastric ulcer is one of the prevalent diseases in racehorses. However, it has not been recognized as important in Korea, and drugs used to treat gastric ulcers are included in the doping test list, so they are not allowed to be administered to racehorses in training. Objectives: This study was performed 1) to investigate the prevalence and the severity of gastric ulcers in Thoroughbred racehorses in Korea, 2) to confirm the therapeutic effect of ranitidine and omeprazole, and 3) to compare the efficacy between ranitidine and omeprazole. Methods: Forty-nine horses were randomly recruited, and gastroscopy was performed within two days after racing. Twelve horses with a sum grade of five or higher were randomly assigned to two treatment groups. Seven horses were administered ranitidine, and five horses were administered omeprazole. Follow-up gastroscopy was scheduled within one to five days after finishing the treatment. Results: The prevalence of gastric ulcer in Korean Thoroughbred racehorses after racing was 100%, and the grade was more severe in the non-glandular region than in the pyloric region. There was no correlation between the severity of gastric ulcer in the two regions. Omeprazole had a greater therapeutic effect than ranitidine. Conclusions: This study shows the importance of recognizing gastric ulcers as an important factor, and omeprazole as a possible treatment option in Korea, as it has been removed from the list of prohibited substances for racehorses. Thus, the use of omeprazole is currently recommended until one day before the race.
Keywords
horses; gastric ulcer; prevalence; ranitidine; omeprazole;
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1 Lavoie JP, Hinchcliff KW. Blackwell's Five-Minute Veterinary Consult: Equine. Hoboken: Wiley-Blackwell; 2011, p 336-339.
2 Hackett ES. Specific causes of colic. In: Southwood LL, editor. Practical Guide to Equine Colic. 1st ed. Hoboken: Wiley-Blackwell; 2013, 205.
3 Murray MJ. Diseases of the stomach. In: White NA, Moore JN, Mair TS, editors. The Equine Acute Abdomen. 2nd ed. Wyoming: Teton New Media; 2008, 577-582.
4 Begg LM, O'Sullivan CB. The prevalence and distribution of gastric ulceration in 345 racehorses. Aust Vet J. 2003;81(4):199-201.   DOI
5 Endo Y, Tsuchiya T, Sato F, Murase H, Omura T, Korosue K, et al. Efficacy of omeprazole paste in the prevention of gastric ulcers in 2 years old Thoroughbreds. J Vet Med Sci. 2012;74(8):1079-1081.   DOI
6 Orsini JA, Haddock M, Stine L, Sullivan EK, Rabuffo TS, Smith G. Odds of moderate or severe gastric ulceration in racehorses receiving antiulcer medications. J Am Vet Med Assoc. 2003;223(3):336-339.   DOI
7 Dionne RM, Vrins A, Doucet MY, Pare J. Gastric ulcers in standardbred racehorses: prevalence, lesion description, and risk factors. J Vet Intern Med. 2003;17(2):218-222.   DOI
8 Banse HE, Andrews FM. Equine glandular gastric disease: prevalence, impact and management strategies. Vet Med (Auckl). 2019;10:69-76.
9 McClure SR, White GW, Sifferman RL, Bernard W, Doucet MY, Vrins A, et al. Efficacy of omeprazole paste for prevention of gastric ulcers in horses in race training. J Am Vet Med Assoc. 2005;226(10):1681-1684.   DOI
10 Sykes BW, Sykes KM, Hallowell GD. A comparison of two doses of omeprazole in the treatment of equine gastric ulcer syndrome: a blinded, randomised, clinical trial. Equine Vet J. 2014;46(4):416-421.   DOI
11 Loftin P, Cartmill JA, Andrews FM. Gastroscopy and esophagoscopy. In: Costa LRR, Paradis MR, editor. Manual of Clinical Procedures in the Horse. 1st ed. Hoboken: Wiley-Blackwell; 2017, 195-200.
12 Sykes BW, Hewetson M, Hepburn RJ, Luthersson N, Tamzali Y. European college of equine internal medicine consensus statement--equine gastric ulcer syndrome in adult horses. J Vet Intern Med. 2015;29(5):1288-1299.   DOI
13 MacAllister CG. A review of medical treatment for peptic ulcer disease. Equine Vet J Suppl. 1999;31(29):45-49.   DOI
14 Murray MJ, Haven ML, Eichorn ES, Zhang D, Eagleson J, Hickey GJ. Effects of omeprazole on healing of naturally-occurring gastric ulcers in Thoroughbred racehorses. Equine Vet J. 1997;29(6):425-429.   DOI
15 Sanchez LC. Disorders of the gastrointestinal system. In: Reed SM, Bayly WM, Sellon DC, editors. Equine Internal Medicine. 3rd ed. Philadelphia: Saunders; 2009, 838-845.
16 Videla R, Andrews FM. New perspectives in equine gastric ulcer syndrome. Vet Clin North Am Equine Pract. 2009;25(2):283-301.   DOI
17 Luthersson N, Nielsen KH, Harris P, Parkin TD. The prevalence and anatomical distribution of equine gastric ulceration syndrome (EGUS) in 201 horses in Denmark. Equine Vet J. 2009;41(7):619-624.   DOI
18 Lester GD, Smith RL, Robertson ID. Effects of treatment with omeprazole or ranitidine on gastric squamous ulceration in racing Thoroughbreds. J Am Vet Med Assoc. 2005;227(10):1636-1639.   DOI
19 Bell RJ, Mogg TD, Kingston JK. Equine gastric ulcer syndrome in adult horses: a review. N Z Vet J. 2007;55(1):1-12.   DOI
20 White G, McClure SR, Sifferman R, Holste JE, Fleishman C, Murray MJ, et al. Effects of short-term light to heavy exercise on gastric ulcer development in horses and efficacy of omeprazole paste in preventing gastric ulceration. J Am Vet Med Assoc. 2007;230(11):1680-1682.   DOI
21 Sykes BW, Jokisalo JM. Rethinking equine gastric ulcer syndrome: part 1-Terminology, clinical signs and diagnosis. Equine Vet Educ. 2014;26(10):543-547.   DOI
22 Murray MJ, Schusser GF, Pipers FS, Gross SJ. Factors associated with gastric lesions in thoroughbred racehorses. Equine Vet J. 1996;28(5):368-374.   DOI
23 McClure SR, Glickman LT, Glickman NW. Prevalence of gastric ulcers in show horses. J Am Vet Med Assoc 1999;215(8):1130-1133.
24 Sykes BW, Sykes KM, Hallowell GD. A comparison between pre- and post-exercise administration of omeprazole in the treatment of EGUS: a randomised, blinded clinical trial. Equine Vet J. 2014;46(4):422-426.   DOI
25 Sykes BW, Sykes KM, Hallowell GD. A comparison of three doses of omeprazole in the treatment of equine gastric ulcer syndrome: a blinded, randomised, dose-response clinical trial. Equine Vet J. 2015;47(3):285-290.   DOI
26 International Federation of Horseracing Authorities. Annual Report 2018. Boulogne: International Federation of Horseracing Authorities; 2018, p 36.
27 McClure SR, Carithers DS, Gross SJ, Murray MJ. Gastric ulcer development in horses in a simulated show or training environment. J Am Vet Med Assoc. 2005;227(5):775-777.   DOI
28 Merritt AM, Sanchez LC, Burrow JA, Church M, Ludzia S. Effect of GastroGard and three compounded oral omeprazole preparations on 24 h intragastric pH in gastrically cannulated mature horses. Equine Vet J. 2003;35(7):691-695.   DOI