Restoration of the adipogenic gene expression by naringenin and naringin in 3T3-L1 adipocytes |
Dayarathne, Lakshi A.
(College of Veterinary Medicine, Jeju National University)
Ranaweera, Sachithra S. (College of Veterinary Medicine, Jeju National University) Natraj, Premkumar (College of Veterinary Medicine, Jeju National University) Rajan, Priyanka (College of Veterinary Medicine, Jeju National University) Lee, Young Jae (College of Veterinary Medicine, Jeju National University) Han, Chang-Hoon (College of Veterinary Medicine, Jeju National University) |
1 | Park J, Kim HL, Jung Y, Ahn KS, Kwak HJ, Um JY. Bitter orange (Citrus aurantium Linne) improves obesity by regulating adipogenesis and thermogenesis through AMPK activation. Nutrients. 2019;11(9):1988. DOI |
2 | Hardie DG, Pan DA. Regulation of fatty acid synthesis and oxidation by the AMP-activated protein kinase. Biochem Soc Trans. 2002;30(Pt 6):1064-1070. DOI |
3 | Claussnitzer M, Skurk T, Hauner H, Daniel H, Rist MJ. Effect of flavonoids on basal and insulin-stimulated 2-deoxyglucose uptake in adipocytes. Mol Nutr Food Res. 2011;55 Suppl 1:S26-S34. DOI |
4 | Ranaweera SS, Dissanayake CY, Natraj P, Lee YJ, Han CH. Anti-inflammatory effect of sulforaphane on LPS-stimulated RAW 264.7 cells and ob/ob mice. J Vet Sci. 2020;21(6):e91. DOI |
5 | Guo X, Liu J, Cai S, Wang O, Ji B. Synergistic interactions of apigenin, naringin, quercetin and emodin on inhibition of 3T3-L1 preadipocyte differentiation and pancreas lipase activity. Obes Res Clin Pract. 2016;10(3):327-339. DOI |
6 | Ha T, Trung TN, Phuong TT, Yim N, Chen QC, Bae K. The selected flavonol glycoside derived from Sophorae Flos improves glucose uptake and inhibits adipocyte differentiation via activation AMPK in 3T3-L1 cells. Bioorg Med Chem Lett. 2010;20(20):6076-6081. DOI |
7 | Bjorbaek C. Central leptin receptor action and resistance in obesity. J Investig Med. 2009;57(7):789-794. DOI |
8 | Alam MA, Subhan N, Rahman MM, Uddin SJ, Reza HM, Sarker SD. Effect of citrus flavonoids, naringin and naringenin, on metabolic syndrome and their mechanisms of action. Adv Nutr. 2014;5(4):404-417. DOI |
9 | Eberle D, Clement K, Meyre D, Sahbatou M, Vaxillaire M, Le Gall A, et al. SREBF-1 gene polymorphisms are associated with obesity and type 2 diabetes in French obese and diabetic cohorts. Diabetes. 2004;53(8):2153-2157. DOI |
10 | Peterfy M, Phan J, Xu P, Reue K. Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin. Nat Genet. 2001;27(1):121-124. DOI |
11 | Lee SH, Park YB, Bae KH, Bok SH, Kwon YK, Lee ES, et al. Cholesterol-lowering activity of naringenin via inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase and acyl coenzyme A:cholesterol acyltransferase in rats. Ann Nutr Metab. 1999;43(3):173-180. DOI |
12 | Hillgartner FB, Salati LM, Goodridge AG. Physiological and molecular mechanisms involved in nutritional regulation of fatty acid synthesis. Physiol Rev. 1995;75(1):47-76. DOI |
13 | Jiang Z, Michal JJ, Tobey DJ, Daniels TF, Rule DC, Macneil MD. Significant associations of stearoyl-CoA desaturase (SCD1) gene with fat deposition and composition in skeletal muscle. Int J Biol Sci. 2008;4(6):345-351. |
14 | Hall AM, Kou K, Chen Z, Pietka TA, Kumar M, Korenblat KM, et al. Evidence for regulated monoacylglycerol acyltransferase expression and activity in human liver. J Lipid Res. 2012;53(5):990-999. DOI |
15 | Constantin RP, Constantin RP, Bracht A, Yamamoto NS, Ishii-Iwamoto EL, Constantin J. Molecular mechanisms of citrus flavanones on hepatic gluconeogenesis. Fitoterapia. 2014;92:148-162. DOI |
16 | Ceddia RB. The role of AMP-activated protein kinase in regulating white adipose tissue metabolism. Mol Cell Endocrinol. 2013;366(2):194-203. DOI |
17 | Jung UJ, Lee MK, Park YB, Kang MA, Choi MS. Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice. Int J Biochem Cell Biol. 2006;38(7):1134-1145. DOI |
18 | Actis Dato V, Chiabrando GA. The role of low-density lipoprotein receptor-related protein 1 in lipid metabolism, glucose homeostasis and inflammation. Int J Mol Sci. 2018;19(6):1780. DOI |
19 | Matsumoto H, Sasaki K, Bessho T, Kobayashi E, Abe T, Sasazaki S, et al. The SNPs in the ACACA gene are effective on fatty acid composition in Holstein milk. Mol Biol Rep. 2012;39(9):8637-8644. DOI |
20 | Guaita-Esteruelas S, Guma J, Masana L, Borras J. The peritumoural adipose tissue microenvironment and cancer. The roles of fatty acid binding protein 4 and fatty acid binding protein 5. Mol Cell Endocrinol. 2018;462(Pt B):107-118. DOI |
21 | Lien DN, Quynh NT, Phuc DV, Phong VC, Huong PT. Effect of pomelo (citrus grandis (l). osbeck) peel extract on lipid-carbohydrate metabolic enzymes and blood lipid, glucose parameters in experimental obese and diabetic mice. VNU J Sci Nat Sci Technol. 2010;26(4):224-232. |
22 | Sun NN, Wu TY, Chau CF. Natural dietary and herbal products in anti-obesity treatment. Molecules. 2016;21(10):1351. DOI |
23 | Morand C, Manach C, Crespy V, Remesy C. Respective bioavailability of quercetin aglycone and its glycosides in a rat model. Biofactors. 2000;12(1-4):169-174. DOI |
24 | Kren V. Glycoside vs. aglycon: the role of glycosidic residue in biological activity. In: Fraser-Reid BO, Tatsuta K, Thiem J, editors. Glycoscience. Berlin: Springer; 2008, 2589-2644. |
25 | Xiao J. Dietary flavonoid aglycones and their glycosides: Which show better biological significance? Crit Rev Food Sci Nutr. 2017;57(9):1874-1905. |
26 | Ribeiro IA, Ribeiro MHL. Naringin and naringenin determination and control in grapefruit juice by a validated HPLC method. Food Control. 2008;19(4):432-438. DOI |
27 | Fang XK, Gao J, Zhu DN. Kaempferol and quercetin isolated from Euonymus alatus improve glucose uptake of 3T3-L1 cells without adipogenesis activity. Life Sci. 2008;82(11-12):615-622. DOI |
28 | Rajappa R, Sireesh D, Salai MB, Ramkumar KM, Sarvajayakesavulu S, Madhunapantula SV. Treatment with naringenin elevates the activity of transcription factor Nrf2 to protect pancreatic β-cells from streptozotocin-induced diabetes in vitro and in vivo. Front Pharmacol. 2019;9:1562. DOI |
29 | Mahmoud AM, Hernandez Bautista RJ, Sandhu MA, Hussein OE. Beneficial effects of citrus flavonoids on cardiovascular and metabolic health. Oxid Med Cell Longev. 2019;2019:5484138. DOI |
30 | Goldwasser J, Cohen PY, Yang E, Balaguer P, Yarmush ML, Nahmias Y. Transcriptional regulation of human and rat hepatic lipid metabolism by the grapefruit flavonoid naringenin: role of PPARalpha, PPARgamma and LXRalpha. PLoS One. 2010;5(8):e12399. DOI |
31 | Gao XF, Chen W, Kong XP, Xu AM, Wang ZG, Sweeney G, et al. Enhanced susceptibility of Cpt1c knockout mice to glucose intolerance induced by a high-fat diet involves elevated hepatic gluconeogenesis and decreased skeletal muscle glucose uptake. Diabetologia. 2009;52(5):912-920. DOI |
32 | Harris CA, Haas JT, Streeper RS, Stone SJ, Kumari M, Yang K, et al. DGAT enzymes are required for triacylglycerol synthesis and lipid droplets in adipocytes. J Lipid Res. 2011;52(4):657-667. DOI |
33 | Smith SJ, Cases S, Jensen DR, Chen HC, Sande E, Tow B, et al. Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat. Nat Genet. 2000;25(1):87-90. DOI |
34 | Bonnefont JP, Djouadi F, Prip-Buus C, Gobin S, Munnich A, Bastin J. Carnitine palmitoyltransferases 1 and 2: biochemical, molecular and medical aspects. Mol Aspects Med. 2004;25(5-6):495-520. DOI |
35 | Morton GJ, Niswender KD, Rhodes CJ, Myers MG Jr, Blevins JE, Baskin DG, et al. Arcuate nucleus-specific leptin receptor gene therapy attenuates the obesity phenotype of Koletsky (fa(k)/fa(k)) rats. Endocrinology. 2003;144(5):2016-2024. DOI |
36 | Kang SW, Kang SI, Shin HS, Yoon SA, Kim JH, Ko HC, et al. Sasa quelpaertensis Nakai extract and its constituent p-coumaric acid inhibit adipogenesis in 3T3-L1 cells through activation of the AMPK pathway. Food Chem Toxicol. 2013;59:380-385. DOI |
37 | Veitch NC, Grayer RJ. Flavonoids and their glycosides, including anthocyanins. Nat Prod Rep. 2011;28(10):1626-1695. DOI |
38 | Havsteen BH. The biochemistry and medical significance of the flavonoids. Pharmacol Ther. 2002;96(2-3):67-202. DOI |
39 | Ameer B, Weintraub RA, Johnson JV, Yost RA, Rouseff RL. Flavanone absorption after naringin, hesperidin, and citrus administration. Clin Pharmacol Ther. 1996;60(1):34-40. DOI |
40 | Xu L, Li Y, Dai Y, Peng J. Natural products for the treatment of type 2 diabetes mellitus: Pharmacology and mechanisms. Pharmacol Res. 2018;130:451-465. DOI |
41 | Richard AJ, Amini-Vaughan Z, Ribnicky DM, Stephens JM. Naringenin inhibits adipogenesis and reduces insulin sensitivity and adiponectin expression in adipocytes. Evid Based Complement Alternat Med. 2013;2013:549750. |
42 | Quintana AM, Hernandez JA, Gonzalez CG. Functional analysis of the zebrafish ortholog of HMGCS1 reveals independent functions for cholesterol and isoprenoids in craniofacial development. PLoS One. 2017;12(7):e0180856. DOI |
43 | Rizzatti V, Boschi F, Pedrotti M, Zoico E, Sbarbati A, Zamboni M. Lipid droplets characterization in adipocyte differentiated 3T3-L1 cells: size and optical density distribution. Eur J Histochem. 2013;57(3):e24. |
44 | Langmead B, Salzberg SL. Fast gapped-read alignment with Bowtie 2. Nat Methods. 2012;9(4):357-359. DOI |
45 | Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, et al. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol. 2004;5(10):R80. DOI |
46 | Hsiu SL, Huang TY, Hou YC, Chin DH, Chao PDL. Comparison of metabolic pharmacokinetics of naringin and naringenin in rabbits. Life Sci. 2002;70(13):1481-1489. DOI |
47 | Kumar S, Pandey AK. Chemistry and biological activities of flavonoids: an overview. Sci World J. 2013;2013:162750. DOI |
48 | Mauvoisin D, Mounier C. Hormonal and nutritional regulation of SCD1 gene expression. Biochimie. 2011;93(1):78-86. DOI |
49 | Pu P, Gao DM, Mohamed S, Chen J, Zhang J, Zhou XY, et al. Naringin ameliorates metabolic syndrome by activating AMP-activated protein kinase in mice fed a high-fat diet. Arch Biochem Biophys. 2012;518(1):61-70. DOI |
50 | Rebello CJ, Greenway FL, Lau FH, Lin Y, Stephens JM, Johnson WD, et al. Naringenin promotes thermogenic gene expression in human white adipose tissue. Obesity (Silver Spring). 2019;27(1):103-111. DOI |
![]() |