Browse > Article
http://dx.doi.org/10.4142/jvs.2021.22.e38

Prevalence of autoantibodies that bind to kidney tissues in cats and association risk with antibodies to feline viral rhinotracheitis, calicivirus, and panleukopenia  

Songaksorn, Nisakorn (Department of Companion Animal and Wildlife Clinic, Faculty of Veterinary Medicine, Chiang Mai University)
Petsophonsakul, Wilaiwan (Department of Microbiology, Faculty of Medicine, Chiang Mai University)
Pringproa, Kidsadagon (Department of Veterinary Bioscience and Veterinary Public Health, Faculty of Veterinary Medicine, Chiang Mai University)
Lampang, Kannika Na (Department of Veterinary Bioscience and Veterinary Public Health, Faculty of Veterinary Medicine, Chiang Mai University)
Sthitmatee, Nattawooti (Department of Veterinary Bioscience and Veterinary Public Health, Faculty of Veterinary Medicine, Chiang Mai University)
Srifawattana, Nuttawan (Small Animal Hospital, Faculty of Veterinary Medicine, Chiang Mai University)
Piyarungsri, Kakanang (Department of Companion Animal and Wildlife Clinic, Faculty of Veterinary Medicine, Chiang Mai University)
Thongkorn, Kriangkrai (Department of Companion Animal and Wildlife Clinic, Faculty of Veterinary Medicine, Chiang Mai University)
Publication Information
Journal of Veterinary Science / v.22, no.3, 2021 , pp. 38.1-38.17 More about this Journal
Abstract
Background: The feline viral rhinotracheitis, calicivirus, and panleukopenia (FVRCP) vaccine, prepared from viruses grown in the Crandell-Rees feline kidney cell line, can induce antibodies to cross-react with feline kidney tissues. Objectives: This study surveyed the prevalence of autoantibodies to feline kidney tissues and their association with the frequency of FVRCP vaccination. Methods: Serum samples and kidneys were collected from 156 live and 26 cadaveric cats. Antibodies that bind to kidney tissues and antibodies to the FVRCP antigen were determined by enzyme-linked immunosorbent assay (ELISA), and kidney-bound antibody patterns were investigated by examining immunofluorescence. Proteins recognized by antibodies were identified by Western blot analysis. Results: The prevalences of autoantibodies that bind to kidney tissues in cats were 41% and 13% by ELISA and immunofluorescence, respectively. Kidney-bound antibodies were observed at interstitial cells, apical border, and cytoplasm of proximal and distal tubules; the antibodies were bound to proteins with molecular weights of 40, 47, 38, and 20 kDa. There was no direct link between vaccination and anti-kidney antibodies, but positive antibodies to kidney tissues were significantly associated with the anti-FVRCP antibody. The odds ratio or association in finding the autoantibody in cats with the antibody to FVRCP was 2.8 times higher than that in cats without the antibody to FVRCP. Conclusions: These preliminary results demonstrate an association between anti-FVRCP and anti-cat kidney tissues. However, an increase in the risk of inducing kidney-bound antibodies by repeat vaccinations could not be shown directly. It will be interesting to expand the sample size and follow-up on whether these autoantibodies can lead to kidney function impairment.
Keywords
Kidney diseases; autoantibodies; vaccines; immunofluorescence; feline;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Prendergast GC, Ziff EB. Mbh 1: a novel gelsolin/severin-related protein which binds actin in vitro and exhibits nuclear localization in vivo. EMBO J. 1991;10(4):757-766.   DOI
2 Baxter KJ, Levy JK, Edinboro CH, Vaden SL, Tompkins MB. Renal disease in cats infected with feline immunodeficiency virus. J Vet Intern Med. 2012;26(2):238-243.   DOI
3 Poli A, Tozon N, Guidi G, Pistello M. Renal alterations in feline immunodeficiency virus (FIV)-infected cats: a natural model of lentivirus-induced renal disease changes. Viruses. 2012;4(9):1372-1389.   DOI
4 Kimmel PL. The nephropathies of HIV infection: pathogenesis and treatment. Curr Opin Nephrol Hypertens. 2000;9(2):117-122.   DOI
5 Lappin MR, Andrews J, Simpson D, Jensen WA. Use of serologic tests to predict resistance to feline herpesvirus 1, feline calicivirus, and feline parvovirus infection in cats. J Am Vet Med Assoc. 2002;220(1):38-42.   DOI
6 Ross SJ, Polzin DJ, Osborne CA. Consultations in feline internal medicine. 5th ed. Saint Louis: W.B. Saunders; 2006, Chapter 42, Clinical progression of early chronic renal failure and implications for management; 389-398.
7 Kohn B, Garner M, Lubke S, Schmidt MF, Bennett D, Brunnberg L. Polyarthritis following vaccination in four dogs. Vet Comp Orthop Traumatol. 2003;16(1):6.   DOI
8 McAnulty JF, Rudd RG. Thrombocytopenia associated with vaccination of a dog with a modified-live paramyxovirus vaccine. J Am Vet Med Assoc 1985.186(11):1217-1219.
9 Duval D, Giger U. Vaccine-associated immune-mediated hemolytic anemia in the dog. J Vet Intern Med. 1996;10(5):290-295.   DOI
10 Hemachudha T, Griffin DE, Giffels JJ, Johnson RT, Moser AB, Phanuphak P. Myelin basic protein as an encephalitogen in encephalomyelitis and polyneuritis following rabies vaccination. N Engl J Med. 1987;316(7):369-374.   DOI
11 Lappin MR, Jensen WA, Jensen TD, Basaraba RJ, Brown CA, Radecki SV, et al. Investigation of the induction of antibodies against Crandell-Rees feline kidney cell lysates and feline renal cell lysates after parenteral administration of vaccines against feline viral rhinotracheitis, calicivirus, and panleukopenia in cats. Am J Vet Res. 2005;66(3):506-511.   DOI
12 Henzel A, Brum MCS, Lovato LT, Weiblen R. Serological survey of feline calicivirus and felid herpesvirus in Rio Grande do Sul, Brazil. Acta Sci Vet. 2013;41:1153.
13 Waisbren BA Sr. Acquired autoimmunity after viral vaccination is caused by molecular mimicry and antigen complimentarity in the presence of an immunologic adjuvant and specific HLA patterns. Med Hypotheses. 2008;70(2):346-348.   DOI
14 De Chiara G, Marcocci ME, Civitelli L, Argnani R, Piacentini R, Ripoli C, et al. APP processing induced by herpes simplex virus type 1 (HSV-1) yields several APP fragments in human and rat neuronal cells. PLoS One. 2010;5(11):e13989.   DOI
15 Mouzin DE, Lorenzen MJ, Haworth JD, King VL. Duration of serologic response to three viral antigens in cats. J Am Vet Med Assoc. 2004;224(1):61-66.   DOI
16 Polzin DJ. Chronic kidney disease in small animals. Vet Clin North Am Small Anim Pract. 2011;41(1):15-30.   DOI
17 Lee YJ, Chan JP, Hsu WL, Lin KW, Chang CC. Prognostic factors and a prognostic index for cats with acute kidney injury. J Vet Intern Med. 2012;26(3):500-505.   DOI
18 Finch NC, Syme HM, Elliott J. Risk factors for development of chronic kidney disease in cats. J Vet Intern Med. 2016;30(2):602-610.   DOI
19 Hegde NR. Cell culture-based influenza vaccines: a necessary and indispensable investment for the future. Hum Vaccin Immunother. 2015;11(5):1223-1234.   DOI
20 Elston T, Rodan H, Flemming D, Ford RB, Hustead DR, Richards JR, et al. 1998 report of the American Association of Feline Practitioners and Academy of Feline Medicine Advisory Panel on Feline Vaccines. J Am Vet Med Assoc. 1998;212(2):227-241.
21 Jakel V, Cussler K, Hanschmann KM, Truyen U, Konig M, Kamphuis E, et al. Vaccination against Feline Panleukopenia: implications from a field study in kittens. BMC Vet Res. 2012;8(1):62-62.   DOI
22 Liberal R, Mieli-Vergani G, Vergani D. Clinical significance of autoantibodies in autoimmune hepatitis. J Autoimmun. 2013;46:17-24.   DOI
23 Enderlein G. Daniel, Wayne W.: Biostatistics - A Foundations for Analysis in the Health Sciences. Wiley & Sons, New York-Chichester-Brisbane-Toronto-Singapore, 6th ed. 1995, 780 S., £58.-, ISBN 0-471-58852-0 (cloth). Biom J. 1995;37(6):744.   DOI
24 Songaksorn N, Petsophonsakul W, Pringproa K, Lampang KN, Sthitmatee N, Sriphawattana N, et al. Production of polyclonal antibody against kidney antigens: a model for studying autoantibody in feline chronic kidney diseases. J Vet Sci. 2019;20(6):e73.   DOI
25 Kochagul V, Srivorakul S, Boonsri K, Somgird C, Sthitmatee N, Thitaram C, et al. Production of antibody against elephant endotheliotropic herpesvirus (EEHV) unveils tissue tropisms and routes of viral transmission in EEHV-infected Asian elephants. Sci Rep. 2018;8(1):4675.   DOI
26 Pringproa K, Madarame H, Sritun J, Bumpenpol P, Pedsri P, Somgird C, et al. Histopathological and immunohistochemical characterization of spontaneous uterine leiomyomas in two captive Asian elephants. Thai J Vet Med. 2015;45(2):289-294.
27 Whittemore JC, Hawley JR, Jensen WA, Lappin MR. Antibodies against Crandell Rees feline kidney (CRFK) cell line antigens, alpha-enolase, and annexin A2 in vaccinated and CRFK hyperinoculated cats. J Vet Intern Med. 2010;24(2):306-313.   DOI
28 Lappin MR, Basaraba RJ, Jensen WA. Interstitial nephritis in cats inoculated with Crandell Rees feline kidney cell lysates. J Feline Med Surg. 2006;8(5):353-356.   DOI
29 Bergmann M, Speck S, Rieger A, Truyen U, Hartmann K. Antibody response to feline calicivirus vaccination in healthy adult cats. Viruses. 2019;11(8):702.   DOI
30 Rosales IA, Collins AB, do Carmo PA, Tolkoff-Rubin N, Smith RN, Colvin RB. Immune complex tubulointerstitial nephritis due to autoantibodies to the proximal tubule brush border. J Am Soc Nephrol. 2016;27(2):380-384.   DOI
31 Dabiri GA, Young CL, Rosenbloom J, Southwick FS. Molecular cloning of human macrophage capping protein cDNA. A unique member of the gelsolin/villin family expressed primarily in macrophages. J Biol Chem. 1992;267(23):16545-16552.   DOI
32 Lawson JS, Syme HM, Wheeler-Jones CPD, Elliott J. Characterisation of Crandell-Rees Feline Kidney (CRFK) cells as mesenchymal in phenotype. Res Vet Sci. 2019;127:99-102.   DOI
33 Srivorakul S, Guntawang T, Kochagul V, Photichai K, Sittisak T, Janyamethakul T, et al. Possible roles of monocytes/macrophages in response to elephant endotheliotropic herpesvirus (EEHV) infections in Asian elephants (Elephas maximus). PLoS One. 2019;14(9):e0222158.   DOI
34 Wucherpfennig KW. Mechanisms for the induction of autoimmunity by infectious agents. J Clin Invest. 2001;108(8):1097-1104.   DOI
35 Kivity S, Agmon-Levin N, Blank M, Shoenfeld Y. Infections and autoimmunity--friends or foes? Trends Immunol. 2009;30(8):409-414.   DOI
36 Grant CK, Fink EA, Sundstrom M, Torbett BE, Elder JH. Improved health and survival of FIV-infected cats is associated with the presence of autoantibodies to the primary receptor, CD134. Proc Natl Acad Sci U S A. 2009;106(47):19980-19985.   DOI
37 Offit PA, Jew RK. Addressing parents' concerns: do vaccines contain harmful preservatives, adjuvants, additives, or residuals? Pediatrics. 2003;112(6 Pt 1):1394-1397.   DOI
38 Lulich J, Osborne C, O'Brien T, Polzin D. Feline renal failure: questions, answers, questions. Compend Contin Educ Vet. 1992;14:127-153.
39 Hogenesch H, Azcona-Olivera J, Scott-Moncrieff C, Snyder PW, Glickman LT. Vaccine-induced autoimmunity in the dog. Adv Vet Med. 1999;41:733-747.   DOI
40 Scott-Moncrieff JC, Azcona-Olivera J, Glickman NW, Glickman LT, HogenEsch H. Evaluation of antithyroglobulin antibodies after routine vaccination in pet and research dogs. J Am Vet Med Assoc. 2002;221(4):515-521.   DOI
41 HogenEsch H. Mechanisms of stimulation of the immune response by aluminum adjuvants. Vaccine. 2002;20 Suppl 3:34-39.   DOI
42 Segal Y, Shoenfeld Y. Vaccine-induced autoimmunity: the role of molecular mimicry and immune crossreaction. Cell Mol Immunol. 2018;15(6):586-594.   DOI
43 Hemachudha T, Griffin DE, Chen WW, Johnson RT. Immunologic studies of rabies vaccination-induced Guillain-Barre syndrome. Neurology. 1988;38(3):375-378.   DOI
44 Latimer KS, Duncan JR. Duncan & Prasse's veterinary laboratory medicine: clinical pathology. 5th ed. Chichester (UK): Wiley-Blackwell; 2011, Chapter 13, Generating and interpreting test results: test validity, quality control, reference values, and basic epidemiology; 374-375.
45 Schultz RD, Thiel B, Mukhtar E, Sharp P, Larson LJ. Age and long-term protective immunity in dogs and cats. J Comp Pathol. 2010;142 Suppl 1:S102-S108.   DOI
46 Jensen WA, Totten JS, Lappin MR, Schultz RD. Use of serologic tests to predict resistance to Canine distemper virus-induced disease in vaccinated dogs. J Vet Diagn Invest. 2015;27(5):576-580.   DOI