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The anti-thrombotic activity of surfactins  

Lim, Jong-Hwan (College of Veterinary Medicine, Chungnam National University)
Park, Byung-Kwon (College of Veterinary Medicine, Chungnam National University)
Kim, Myoung-Seok (College of Veterinary Medicine, Chungnam National University)
Hwang, Mi-Hyun (College of Veterinary Medicine, Kyungpook National University)
Rhee, Man-Hee (College of Veterinary Medicine, Kyungpook National University)
Park, Seung-Chun (College of Veterinary Medicine, Kyungpook National University)
Yun, Hyo-In (College of Veterinary Medicine, Chungnam National University)
Publication Information
Journal of Veterinary Science / v.6, no.4, 2005 , pp. 353-355 More about this Journal
Abstract
Platelet aggregation was inhibited and the density of platelet-rich plasma (PRP) clots was decreased by the preincubation of PRP with surfactins, an acidic lipopeptide of Bacillus subtilis complex BC1212 isolated from soybean paste, in dose-dependent manner. Our findings suggest that surfactins are able to prevent a platelet aggregation leading to an inhibition of additional fibrin clot formation, and to enhance fibrinolysis with facilitated diffusion of fibrinolytic agents.
Keywords
anti-platelet aggregation; platelet rich plasma; surfactins;
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Times Cited By KSCI : 4  (Citation Analysis)
Times Cited By SCOPUS : 13
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