Browse > Article
http://dx.doi.org/10.3348/kjr.2016.17.3.424

Imaging Spectrum and Pitfalls of 11C-Methionine Positron Emission Tomography in a Series of Patients with Intracranial Lesions  

Ito, Kimiteru (Department of Radiology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology)
Matsuda, Hiroshi (Integrative Brain Imaging Center, National Center of Neurology and Psychiatry)
Kubota, Kazoo (Division of Nuclear Medicine, National Center for Global Health and Medicine)
Publication Information
Korean Journal of Radiology / v.17, no.3, 2016 , pp. 424-434 More about this Journal
Abstract
$^{11}C$-methionine (Met) positron emission tomography (PET) is one of the most commonly used PET tracers for evaluating brain tumors. However, few reports have described tips and pitfalls of $^{11}C$-Met PET for general practitioners. Physiological $^{11}C$-Met uptake, anatomical variations, vascular disorders, non-tumorous lesions such as inflammation or dysplasia, benign brain tumors and patient condition during $^{11}C$-Met PET examination can potentially affect the image interpretation and cause false positives and negatives. These pitfalls in the interpretation of $^{11}C$-Met PET images are important for not only nuclear medicine physicians but also general radiologists. Familiarity with the spectrum and pitfalls of $^{11}C$-Met images could help prevent unfavorable clinical results caused by misdiagnoses.
Keywords
Methionine; Positron-emission tomography; Brain tumors; Vascular diseases; Inflammation;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Zhao C, Zhang Y, Wang J. A meta-analysis on the diagnostic performance of (18)F-FDG and (11)C-methionine PET for differentiating brain tumors. AJNR Am J Neuroradiol 2014;35:1058-1065   DOI
2 Singhal T, Narayanan TK, Jain V, Mukherjee J, Mantil J. 11C-L-methionine positron emission tomography in the clinical management of cerebral gliomas. Mol Imaging Biol 2008;10:1-18   DOI
3 Glaudemans AW, Enting RH, Heesters MA, Dierckx RA, van Rheenen RW, Walenkamp AM, et al. Value of 11C-methionine PET in imaging brain tumours and metastases. Eur J Nucl Med Mol Imaging 2013;40:615-635   DOI
4 Nagata T, Tsuyuguchi N, Uda T, Terakawa Y, Takami T, Ohata K. Examination of 11C-methionine metabolism by the standardized uptake value in the normal brain of children. J Nucl Med 2011;52:201-205   DOI
5 Lindholm P, Leskinen-Kallio S, Kirvela O, Nagren K, Lehikoinen P, Pulkki K, et al. Head and neck cancer: effect of food ingestion on uptake of C-11 methionine. Radiology 1994;190:863-867   DOI
6 Torii K, Tsuyuguchi N, Kawabe J, Sunada I, Hara M, Shiomi S. Correlation of amino-acid uptake using methionine PET and histological classifications in various gliomas. Ann Nucl Med 2005;19:677-683   DOI
7 Tomura N, Ito Y, Matsuoka H, Saginoya T, Numazawa SI, Mizuno Y, et al. PET findings of intramedullary tumors of the spinal cord using [18F] FDG and [11C] methionine. AJNR Am J Neuroradiol 2013;34:1278-1283   DOI
8 Kawase Y, Yamamoto Y, Kameyama R, Kawai N, Kudomi N, Nishiyama Y. Comparison of 11C-methionine PET and 18F-FDG PET in patients with primary central nervous system lymphoma. Mol Imaging Biol 2011;13:1284-1289   DOI
9 Okochi Y, Nihashi T, Fujii M, Kato K, Okada Y, Ando Y, et al. Clinical use of (11)C-methionine and (18)F-FDG-PET for germinoma in central nervous system. Ann Nucl Med 2014;28:94-102   DOI
10 Phi JH, Paeng JC, Lee HS, Wang KC, Cho BK, Lee JY, et al. Evaluation of focal cortical dysplasia and mixed neuronal and glial tumors in pediatric epilepsy patients using 18F-FDG and 11C-methionine pet. J Nucl Med 2010;51:728-734   DOI
11 Arita H, Kinoshita M, Okita Y, Hirayama R, Watabe T, Ishohashi K, et al. Clinical characteristics of meningiomas assessed by $^{11}C$-methionine and $^{18}F$-fluorodeoxyglucose positron-emission tomography. J Neurooncol 2012;107:379-386   DOI
12 Takao H, Momose T, Ohtomo K. Methionine and glucose metabolism of central neurocytoma: a PET study. Clin Nucl Med 2004;29:838-839   DOI
13 Nakagawa M, Kuwabara Y, Sasaki M, Koga H, Chen T, Kaneko O, et al. 11C-methionine uptake in cerebrovascular disease: a comparison with 18F-fDG PET and 99mTc-HMPAO SPECT. Ann Nucl Med 2002;16:207-211   DOI
14 Harada Y, Hirata K, Kobayashi H, Usui R, Shiga T, Terae S, et al. A pitfall of C-11 methionine PET: cerebral venous infarction mimicked a glioma. Clin Nucl Med 2012;37:110-111   DOI
15 O'Doherty MJ, Barrington SF, Campbell M, Lowe J, Bradbeer CS. PET scanning and the human immunodeficiency virus-positive patient. J Nucl Med 1997;38:1575-1583
16 Sasaki M, Kuwabara Y, Yoshida T, Fukumura T, Morioka T, Nishio S, et al. Carbon-11-methionine PET in focal cortical dysplasia: a comparison with fluorine-18-FDG PET and technetium-99m-ECD SPECT. J Nucl Med 1998;39:974-977