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http://dx.doi.org/10.3348/kjr.2016.17.2.281

F-18 Sodium Fluoride Positron Emission Tomography/Computed Tomography for Detection of Thyroid Cancer Bone Metastasis Compared with Bone Scintigraphy  

Lee, Hyunjong (Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine)
Lee, Won Woo (Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine)
Park, So Yeon (Department of Pathology, Seoul National University Bundang Hospital, Seoul National University College of Medicine)
Kim, Sang Eun (Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine)
Publication Information
Korean Journal of Radiology / v.17, no.2, 2016 , pp. 281-288 More about this Journal
Abstract
Objective: The aim of the study was to compare the diagnostic performances of F-18 sodium fluoride positron emission tomography/computed tomography (bone PET/CT) and bone scintigraphy (BS) for the detection of thyroid cancer bone metastasis. Materials and Methods: We retrospectively enrolled 6 thyroid cancer patients (age = $44.7{\pm}9.8$ years, M:F = 1:5, papillary:follicular = 2:4) with suspected bone metastatic lesions in the whole body iodine scintigraphy or BS, who subsequently underwent bone PET/CT. Pathologic diagnosis was conducted for 4 lesions of 4 patients. Results: Of the 17 suspected bone lesions, 10 were metastatic and 7 benign. Compared to BS, bone PET/CT exhibited superior sensitivity (10/10 = 100% vs. 2/10 = 20%, p = 0.008), and accuracy (14/17 = 82.4% vs. 7/17 = 41.2%, p < 0.025). The specificity (4/7 = 57.1%) of bone PET/CT was not significantly different from that of BS (5/7 = 71.4%, p > 0.05). Conclusion: Bone PET/CT may be more sensitive and accurate than BS for the detection of thyroid cancer bone metastasis.
Keywords
Thyroid cancer; Bone metastasis; Bone scintigraphy; F-18 sodium fluoride; Positron emission tomography;
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Times Cited By KSCI : 3  (Citation Analysis)
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