Browse > Article
http://dx.doi.org/10.3348/kjr.2015.16.6.1207

Troubleshooting Arterial-Phase MR Images of Gadoxetate Disodium-Enhanced Liver  

Huh, Jimi (Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine)
Kim, So Yeon (Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine)
Yeh, Benjamin M. (Department of Radiology and Biomedical Imaging, University of California San Francisco)
Lee, Seung Soo (Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine)
Kim, Kyoung Won (Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine)
Wu, En-Haw (Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital, Linkou and Chang Gung University College of Medicine)
Wang, Z. Jane (Department of Radiology and Biomedical Imaging, University of California San Francisco)
Zhao, Li-qin (Beijing Friendship Hospital, Capital Medical University)
Chang, Wei Chou (Tri-Service General Hospital and National Defense Medical Center)
Publication Information
Korean Journal of Radiology / v.16, no.6, 2015 , pp. 1207-1215 More about this Journal
Abstract
Gadoxetate disodium is a widely used magnetic resonance (MR) contrast agent for liver MR imaging, and it provides both dynamic and hepatobiliary phase images. However, acquiring optimal arterial phase images at liver MR using gadoxetate disodium is more challenging than using conventional extracellular MR contrast agent because of the small volume administered, the gadolinium content of the agent, and the common occurrence of transient severe motion. In this article, we identify the challenges in obtaining high-quality arterial-phase images of gadoxetate disodium-enhanced liver MR imaging and present strategies for optimizing arterial-phase imaging based on the thorough review of recent research in this field.
Keywords
Gadoxetate disodium; Magnetic resonance imaging; Arterial phase; Liver; Transient severe motion;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Haradome H, Grazioli L, Tsunoo M, Tinti R, Frittoli B, Gambarini S, et al. Can MR fluoroscopic triggering technique and slow rate injection provide appropriate arterial phase images with reducing artifacts on gadoxetic acid-DTPA (Gd- EOB-DTPA)-enhanced hepatic MR imaging? J Magn Reson Imaging 2010;32:334-340   DOI
2 Chung SH, Kim MJ, Choi JY, Hong HS. Comparison of two different injection rates of gadoxetic acid for arterial phase MRI of the liver. J Magn Reson Imaging 2010;31:365-372   DOI
3 Schmid-Tannwald C, Herrmann K, Oto A, Panteleon A, Reiser M, Zech C. Optimization of the dynamic, Gd-EOB-DTPA-enhanced MRI of the liver: the effect of the injection rate. Acta Radiol 2012;53:961-965   DOI
4 Kim SM, Heo SH, Kim JW, Lim HS, Shin SS, Jeong YY, et al. Hepatic arterial phase on gadoxetic acid-enhanced liver MR imaging: a randomized comparison of 0.5 mL/s and 1 mL/s injection rates. Korean J Radiol 2014;15:605-612   DOI
5 Bashir MR, Gupta RT, Davenport MS, Allen BC, Jaffe TA, Ho LM, et al. Hepatocellular carcinoma in a North American population: does hepatobiliary MR imaging with Gd-EOB-DTPA improve sensitivity and confidence for diagnosis? J Magn Reson Imaging 2013;37:398-406   DOI
6 Motosugi U, Ichikawa T, Sano K, Sou H, Onohara K, Muhi A, et al. Double-dose gadoxetic Acid-enhanced magnetic resonance imaging in patients with chronic liver disease. Invest Radiol 2011;46:141-145   DOI
7 Motosugi U, Ichikawa T, Sou H, Sano K, Ichikawa S, Tominaga L, et al. Dilution method of gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI). J Magn Reson Imaging 2009;30:849-854   DOI
8 Park YS, Lee CH, Kim IS, Kiefer B, Woo ST, Kim KA, et al. Usefulness of controlled aliasing in parallel imaging results in higher acceleration in gadoxetic acid-enhanced liver magnetic resonance imaging to clarify the hepatic arterial phase. Invest Radiol 2014;49:183-188   DOI
9 Goshima S, Kanematsu M, Kondo H, Watanabe H, Kawada H, Moriyama N, et al. Evaluation of optimal scan delay for gadoxetate disodium-enhanced hepatic arterial phase MRI using MR fluoroscopic triggering and slow injection technique. AJR Am J Roentgenol 2013;201:578-582   DOI
10 Hussain HK, Londy FJ, Francis IR, Nghiem HV, Weadock WJ, Gebremariam A, et al. Hepatic arterial phase MR imaging with automated bolus-detection three-dimensional fast gradientrecalled- echo sequence: comparison with test-bolus method. Radiology 2003;226:558-566   DOI
11 Lee VS, Lavelle MT, Rofsky NM, Laub G, Thomasson DM, Krinsky GA, et al. Hepatic MR imaging with a dynamic contrast-enhanced isotropic volumetric interpolated breathhold examination: feasibility, reproducibility, and technical quality. Radiology 2000;215:365-372   DOI
12 Rofsky NM, Lee VS, Laub G, Pollack MA, Krinsky GA, Thomasson D, et al. Abdominal MR imaging with a volumetric interpolated breath-hold examination. Radiology 1999;212:876-884   DOI
13 Guglielmo FF, Mitchell DG, Gupta S. Gadolinium contrast agent selection and optimal use for body MR imaging. Radiol Clin North Am 2014;52:637-656   DOI
14 McKenzie CA, Lim D, Ransil BJ, Morrin M, Pedrosa I, Yeh EN, et al. Shortening MR image acquisition time for volumetric interpolated breath-hold examination with a recently developed parallel imaging reconstruction technique: clinical feasibility. Radiology 2004;230:589-594   DOI
15 Budjan J, Ong M, Riffel P, Morelli JN, Michaely HJ, Schoenberg SO, et al. CAIPIRINHA-Dixon-TWIST (CDT)-volumeinterpolated breath-hold examination (VIBE) for dynamic liver imaging: comparison of gadoterate meglumine, gadobutrol and gadoxetic acid. Eur J Radiol 2014;83:2007-2012   DOI
16 Vogt FM, Antoch G, Hunold P, Maderwald S, Ladd ME, Debatin JF, et al. Parallel acquisition techniques for accelerated volumetric interpolated breath-hold examination magnetic resonance imaging of the upper abdomen: assessment of image quality and lesion conspicuity. J Magn Reson Imaging 2005;21:376-382   DOI
17 Kim KW, Lee JM, Jeon YS, Kang SE, Baek JH, Han JK, et al. Free-breathing dynamic contrast-enhanced MRI of the abdomen and chest using a radial gradient echo sequence with K-space weighted image contrast (KWIC). Eur Radiol 2013;23:1352-1360   DOI
18 Fujinaga Y, Ohya A, Tokoro H, Yamada A, Ueda K, Ueda H, et al. Radial volumetric imaging breath-hold examination (VIBE) with k-space weighted image contrast (KWIC) for dynamic gadoxetic acid (Gd-EOB-DTPA)-enhanced MRI of the liver: advantages over Cartesian VIBE in the arterial phase. Eur Radiol 2014;24:1290-1299   DOI
19 Soher BJ, Dale BM, Merkle EM. A review of MR physics: 3T versus 1.5T. Magn Reson Imaging Clin N Am 2007;15:277-290, v   DOI
20 Boll DT, Merkle EM. Imaging at higher magnetic fields: 3 T versus 1.5 T. Magn Reson Imaging Clin N Am 2010;18:549-564, xi-xii   DOI
21 Tanimoto A, Higuchi N, Ueno A. Reduction of ringing artifacts in the arterial phase of gadoxetic acid-enhanced dynamic MR imaging. Magn Reson Med Sci 2012;11:91-97   DOI
22 Mitchell DG, Bruix J, Sherman M, Sirlin CB. LI-RADS (Liver Imaging Reporting and Data System): summary, discussion, and consensus of the LI-RADS Management Working Group and future directions. Hepatology 2015;61:1056-1065   DOI
23 Secil M, Obuz F, Altay C, Gencel O, Igci E, Sagol O, et al. The role of dynamic subtraction MRI in detection of hepatocellular carcinoma. Diagn Interv Radiol 2008;14:200-204
24 Yu JS, Kim YH, Rofsky NM. Dynamic subtraction magnetic resonance imaging of cirrhotic liver: assessment of high signal intensity lesions on nonenhanced T1-weighted images. J Comput Assist Tomogr 2005;29:51-58   DOI
25 An C, Park MS, Kim D, Kim YE, Chung WS, Rhee H, et al. Added value of subtraction imaging in detecting arterial enhancement in small (<3 cm) hepatic nodules on dynamic contrast-enhanced MRI in patients at high risk of hepatocellular carcinoma. Eur Radiol 2013;23:924-930   DOI
26 Kudo M. Will Gd-EOB-MRI change the diagnostic algorithm in hepatocellular carcinoma? Oncology 2010;78 Suppl 1:87-93
27 Fowler KJ, Brown JJ, Narra VR. Magnetic resonance imaging of focal liver lesions: approach to imaging diagnosis. Hepatology 2011;54:2227-2237   DOI
28 Bruix J, Sherman M; American Association for the Study of Liver Diseases. Management of hepatocellular carcinoma: an update. Hepatology 2011;53:1020-1022   DOI
29 Lencioni R, Llovet JM. Modified RECIST (mRECIST) assessment for hepatocellular carcinoma. Semin Liver Dis 2010;30:52-60   DOI
30 Brismar TB, Dahlstrom N, Edsborg N, Persson A, Smedby O, Albiin N. Liver vessel enhancement by Gd-BOPTA and Gd- EOB-DTPA: a comparison in healthy volunteers. Acta Radiol 2009;50:709-715   DOI
31 Tamada T, Ito K, Sone T, Yamamoto A, Yoshida K, Kakuba K, et al. Dynamic contrast-enhanced magnetic resonance imaging of abdominal solid organ and major vessel: comparison of enhancement effect between Gd-EOB-DTPA and Gd-DTPA. J Magn Reson Imaging 2009;29:636-640   DOI
32 Davenport MS, Viglianti BL, Al-Hawary MM, Caoili EM, Kaza RK, Liu PS, et al. Comparison of acute transient dyspnea after intravenous administration of gadoxetate disodium and gadobenate dimeglumine: effect on arterial phase image quality. Radiology 2013;266:452-461   DOI
33 Vogl TJ, Kümmel S, Hammerstingl R, Schellenbeck M, Schumacher G, Balzer T, et al. Liver tumors: comparison of MR imaging with Gd-EOB-DTPA and Gd-DTPA. Radiology 1996;200:59-67   DOI
34 Cruite I, Schroeder M, Merkle EM, Sirlin CB. Gadoxetate disodium-enhanced MRI of the liver: part 2, protocol optimization and lesion appearance in the cirrhotic liver. AJR Am J Roentgenol 2010;195:29-41   DOI
35 Ringe KI, Husarik DB, Sirlin CB, Merkle EM. Gadoxetate disodium-enhanced MRI of the liver: part 1, protocol optimization and lesion appearance in the noncirrhotic liver. AJR Am J Roentgenol 2010;195:13-28   DOI
36 Tamada T, Ito K, Yoshida K, Kanki A, Higaki A, Tanimoto D, et al. Comparison of three different injection methods for arterial phase of Gd-EOB-DTPA enhanced MR imaging of the liver. Eur J Radiol 2011;80:e284-e288   DOI
37 Rohrer M, Bauer H, Mintorovitch J, Requardt M, Weinmann HJ. Comparison of magnetic properties of MRI contrast media solutions at different magnetic field strengths. Invest Radiol 2005;40:715-724   DOI
38 Zech CJ, Vos B, Nordell A, Urich M, Blomqvist L, Breuer J, et al. Vascular enhancement in early dynamic liver MR imaging in an animal model: comparison of two injection regimen and two different doses Gd-EOB-DTPA (gadoxetic acid) with standard Gd-DTPA. Invest Radiol 2009;44:305-310   DOI
39 Bae KT. Intravenous contrast medium administration and scan timing at CT: considerations and approaches. Radiology 2010;256:32-61   DOI
40 Bae KT. Peak contrast enhancement in CT and MR angiography: when does it occur and why? Pharmacokinetic study in a porcine model. Radiology 2003;227:809-816   DOI
41 Pietryga JA, Burke LM, Marin D, Jaffe TA, Bashir MR. Respiratory motion artifact affecting hepatic arterial phase imaging with gadoxetate disodium: examination recovery with a multiple arterial phase acquisition. Radiology 2014;271:426-434   DOI
42 Tirkes T, Mehta P, Aisen AM, Lall C, Akisik F. Comparison of Dynamic Phase Enhancement of Hepatocellular Carcinoma Using Gadoxetate Disodium vs Gadobenate Dimeglumine. J Comput Assist Tomogr 2015;39:479-482   DOI
43 Kim HJ, Kim BS, Kim MJ, Kim SH, de Campos RO, Hernandes M, et al. Enhancement of the liver and pancreas in the hepatic arterial dominant phase: comparison of hepatocytespecific MRI contrast agents, gadoxetic acid and gadobenate dimeglumine, on 3 and 1.5 Tesla MRI in the same patient. J Magn Reson Imaging 2013;37:903-908   DOI
44 Davenport MS, Caoili EM, Kaza RK, Hussain HK. Matched within-patient cohort study of transient arterial phase respiratory motion-related artifact in MR imaging of the liver: gadoxetate disodium versus gadobenate dimeglumine. Radiology 2014;272:123-131   DOI
45 Kim SY, Park SH, Wu EH, Wang ZJ, Hope TA, Chang WC, et al. Transient respiratory motion artifact during arterial phase MRI with gadoxetate disodium: risk factor analyses. AJR Am J Roentgenol 2015;204:1220-1227   DOI
46 Bashir MR, Castelli P, Davenport MS, Larson D, Marin D, Hussain HK, et al. Respiratory motion artifact affecting hepatic arterial phase MR imaging with gadoxetate disodium is more common in patients with a prior episode of arterial phase motion associated with gadoxetate disodium. Radiology 2015;274:141-148   DOI